85527

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2225389..2226077 Replicon chromosome
Accession NZ_CP023636
Organism Mycobacterium tuberculosis strain TBDM2699

Toxin (Protein)


Gene name vapC Uniprot ID P9WF64
Locus tag CP493_RS10770 Protein ID WP_003899117.1
Coordinates 2225389..2225808 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag CP493_RS10775 Protein ID WP_003409968.1
Coordinates 2225817..2226077 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP493_RS10750 2220884..2221732 + 849 WP_003409942.1 class I SAM-dependent methyltransferase -
CP493_RS10755 2221695..2223140 - 1446 WP_003899115.1 APC family permease -
CP493_RS10760 2223319..2224005 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
CP493_RS10765 2224196..2225164 - 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
CP493_RS10770 2225389..2225808 - 420 WP_003899117.1 type II toxin-antitoxin system VapC family toxin Toxin
CP493_RS10775 2225817..2226077 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
CP493_RS10780 2226220..2227896 + 1677 WP_003899118.1 PecA family PE domain-processing aspartic protease -
CP493_RS10785 2227884..2228537 - 654 WP_003409976.1 cutinase Cfp21 -
CP493_RS10790 2228652..2228882 + 231 WP_003409980.1 DUF167 domain-containing protein -
CP493_RS10795 2228967..2229878 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
CP493_RS10800 2229987..2230586 + 600 WP_003409989.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14748.87 Da        Isoelectric Point: 7.9722

>T85527 WP_003899117.1 NZ_CP023636:c2225808-2225389 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDHEFRGVVGYWPGVA

Download         Length: 420 bp

>T85527 NZ_CP023636:c2225808-2225389 [Mycobacterium tuberculosis]
ATGATCGTGGACACAAGCGCCGTGGTGGCCCTGGTTCAAGGCGAGCGGCCGCACGCCACCCTGGTCGCGGCCGCCCTGGC
CGGCGCCCATAGCCCCGTCATGTCTGCACCCACCGTCGCCGAATGCCTGATTGTCTTGACCGCCCGTCACGGCCCCGTTG
CGCGCACGATCTTCGAACGACTTCGCAGCGAAATCGGCTTGAGCGTGTCATCTTTCACCGCCGAGCATGCCGCTGCCACG
CAACGAGCCTTTCTGCGATACGGCAAGGGGCGCCACCGCGCGGCTCTCAACTTCGGAGACTGTATGACGTACGCGACCGC
CCAGCTGGGCCACCAACCACTGCTGGCCGTCGGCAACGACTTCCCGCAAACCGACCATGAGTTCCGCGGCGTCGTCGGCT
ACTGGCCAGGCGTCGCGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT85527 WP_003409968.1 NZ_CP023636:c2226077-2225817 [Mycobacterium tuberculosis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT85527 NZ_CP023636:c2226077-2225817 [Mycobacterium tuberculosis]
GTGGCGCTGAATATCAAAGACCCTGAGGTAGACCGACTAGCCGCCGAACTCGCTGACCGGCTGCACACCAGCAAGACTGC
CGCCATCCGGCATGCCCTGTCTGCCCAGCTGGCGTTTTTGGAGTCGCGCGCCGGCGACCGTGAGGCACAACTTCTCGACA
TCTTGCGTACCGAAATCTGGCCCCTGCTTGCCGACCGCTCCCCCATCACCAAGCTCGAGCGCGAACAAATCCTCGGCTAC
GACCCCGCAACCGGAGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E7TLI0

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References