Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/PIN_Sll0205-like-Phd
Location 3136454..3137058 Replicon chromosome
Accession NZ_CP023632
Organism Mycobacterium tuberculosis strain TBDM2189

Toxin (Protein)


Gene name vapC Uniprot ID P71623
Locus tag CP489_RS15455 Protein ID WP_003414492.1
Coordinates 3136454..3136846 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A829CBY8
Locus tag CP489_RS15460 Protein ID WP_003414495.1
Coordinates 3136843..3137058 (-) Length 72 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP489_RS15425 3131604..3132392 - 789 WP_176747983.1 CRISPR-associated endoribonuclease Cas6 -
CP489_RS15430 3132726..3133271 - 546 WP_003913758.1 DUF1802 family protein -
CP489_RS15435 3133543..3134427 - 885 WP_003414409.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
CP489_RS15440 3134430..3135317 - 888 WP_003414414.1 type IV toxin-antitoxin system AbiEi family antitoxin -
CP489_RS15445 3135622..3136167 - 546 WP_003899500.1 DUF1802 family protein -
CP489_RS15450 3136164..3136433 - 270 WP_003414489.1 DUF2277 family protein -
CP489_RS15455 3136454..3136846 - 393 WP_003414492.1 type II toxin-antitoxin system VapC family toxin Toxin
CP489_RS15460 3136843..3137058 - 216 WP_003414495.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CP489_RS15465 3137105..3137854 + 750 WP_003414497.1 enoyl-CoA hydratase -
CP489_RS15470 3137933..3139015 - 1083 WP_070890572.1 ABC transporter ATP-binding protein -
CP489_RS15475 3139008..3140318 - 1311 WP_003414501.1 ABC transporter substrate-binding protein -
CP489_RS15480 3140321..3141148 - 828 WP_003414504.1 carbohydrate ABC transporter permease -
CP489_RS15485 3141145..3142056 - 912 WP_003414505.1 sugar ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 131 a.a.        Molecular weight: 14610.74 Da        Isoelectric Point: 6.7594

>T85302 WP_003414492.1 NZ_CP023632:c3136846-3136454 [Mycobacterium tuberculosis]
MTTVLLDSHVAYWWSAEPQRLSMAASQAIEHADELAVAAISWFELAWLAEQERIQLAIPVLSWLQQLAEHVRTVGITPSV
AATAVALPSSFPGDPADRLIYATAIEHGWRLVTKDRRLRSHRHPRPVTVW

Download         Length: 393 bp

>T85302 NZ_CP023632:c3136846-3136454 [Mycobacterium tuberculosis]
ATGACGACGGTGCTGCTCGACTCGCATGTGGCCTACTGGTGGTCGGCCGAGCCGCAGCGTCTCAGCATGGCGGCGAGCCA
GGCCATCGAACACGCCGACGAGCTCGCCGTCGCCGCGATTTCGTGGTTCGAGCTGGCTTGGCTTGCCGAACAGGAACGCA
TCCAACTGGCGATTCCGGTGCTGTCCTGGCTTCAGCAGCTGGCCGAGCACGTTCGCACCGTCGGTATCACGCCCTCGGTC
GCCGCCACGGCGGTGGCGCTGCCCTCGTCGTTCCCCGGCGATCCGGCCGACCGGTTGATCTACGCCACCGCGATCGAACA
CGGCTGGCGGCTGGTGACCAAGGACCGGCGGCTACGCAGTCATCGGCACCCACGACCGGTCACCGTCTGGTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7511.55 Da        Isoelectric Point: 4.9732

>AT85302 WP_003414495.1 NZ_CP023632:c3137058-3136843 [Mycobacterium tuberculosis]
MTATEVKAKILSLLDEVAQGEEIEITKHGRTVARLVAATGPHALKGRFSGVAMAAVDDDELFTTGVSWNVS

Download         Length: 216 bp

>AT85302 NZ_CP023632:c3137058-3136843 [Mycobacterium tuberculosis]
ATGACCGCTACGGAGGTGAAGGCGAAGATCCTCTCCTTGCTTGATGAAGTGGCCCAGGGCGAGGAGATCGAGATCACCAA
ACACGGCCGCACCGTGGCCCGGCTGGTGGCAGCGACGGGGCCGCACGCGCTGAAGGGTCGATTCTCGGGTGTGGCGATGG
CGGCCGTGGATGACGACGAACTCTTCACCACCGGGGTTTCGTGGAACGTTTCATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7U4BWM8


Antitoxin

Source ID Structure
AlphaFold DB A0A829CBY8

References