Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2203543..2204087 Replicon chromosome
Accession NZ_CP023631
Organism Mycobacterium tuberculosis strain TBDM1506

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag CP487_RS10630 Protein ID WP_003409896.1
Coordinates 2203543..2203839 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag CP487_RS10635 Protein ID WP_003409899.1
Coordinates 2203836..2204087 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP487_RS10575 2198576..2198926 - 351 WP_003899096.1 hypothetical protein -
CP487_RS10580 2198937..2199839 - 903 WP_003899097.1 hypothetical protein -
CP487_RS10585 2199860..2200051 - 192 WP_003409876.1 hypothetical protein -
CP487_RS10590 2200052..2200348 - 297 WP_003409877.1 hypothetical protein -
CP487_RS10595 2200588..2200803 + 216 WP_003409878.1 antitoxin -
CP487_RS10600 2200800..2201111 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
CP487_RS21795 2201085..2201606 - 522 WP_003904745.1 hypothetical protein -
CP487_RS10610 2201581..2201958 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
CP487_RS10615 2202000..2202449 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
CP487_RS10620 2202446..2202991 + 546 WP_003899098.1 SecB-like chaperone -
CP487_RS10625 2202880..2203494 - 615 WP_003901296.1 hypothetical protein -
CP487_RS10630 2203543..2203839 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CP487_RS10635 2203836..2204087 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
CP487_RS10640 2204074..2204568 + 495 WP_003899099.1 hypothetical protein -
CP487_RS10645 2204728..2205135 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
CP487_RS10650 2205139..2205411 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
CP487_RS10655 2205444..2206664 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
CP487_RS10670 2207563..2208360 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T85222 WP_003409896.1 NZ_CP023631:c2203839-2203543 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T85222 NZ_CP023631:c2203839-2203543 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT85222 WP_003409899.1 NZ_CP023631:c2204087-2203836 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT85222 NZ_CP023631:c2204087-2203836 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References