Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3770673..3771202 Replicon chromosome
Accession NZ_CP023630
Organism Mycobacterium tuberculosis strain MDRMA2441

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag CP486_RS18395 Protein ID WP_003417760.1
Coordinates 3770945..3771202 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag CP486_RS18390 Protein ID WP_003417757.1
Coordinates 3770673..3770948 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP486_RS21950 3767471..3768908 - 1438 Protein_3470 FAD-binding oxidoreductase -
CP486_RS18375 3769011..3769400 + 390 WP_003417745.1 DUF732 domain-containing protein -
CP486_RS18380 3769414..3769707 - 294 WP_003417749.1 DUF3017 domain-containing protein -
CP486_RS18385 3769704..3770549 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
CP486_RS18390 3770673..3770948 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
CP486_RS18395 3770945..3771202 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
CP486_RS18400 3771244..3772434 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
CP486_RS18405 3772551..3772919 + 369 WP_003417765.1 FHA domain-containing protein -
CP486_RS18410 3772916..3773467 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
CP486_RS18415 3773474..3774055 - 582 WP_003417769.1 ATP/GTP-binding protein -
CP486_RS18420 3774036..3774404 - 369 WP_003417772.1 DUF742 domain-containing protein -
CP486_RS18425 3774382..3774774 - 393 WP_003417776.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T85186 WP_003417760.1 NZ_CP023630:3770945-3771202 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T85186 NZ_CP023630:3770945-3771202 [Mycobacterium tuberculosis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT85186 WP_003417757.1 NZ_CP023630:3770673-3770948 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT85186 NZ_CP023630:3770673-3770948 [Mycobacterium tuberculosis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References