Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2402136..2402665 Replicon chromosome
Accession NZ_CP023630
Organism Mycobacterium tuberculosis strain MDRMA2441

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag CP486_RS11655 Protein ID WP_003411124.1
Coordinates 2402136..2402453 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag CP486_RS11660 Protein ID WP_003411127.1
Coordinates 2402450..2402665 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP486_RS11625 2397273..2398349 + 1077 WP_003411110.1 hypothetical protein -
CP486_RS11630 2398346..2398627 + 282 WP_024748354.1 hypothetical protein -
CP486_RS11635 2398663..2399736 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
CP486_RS11640 2399741..2400271 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
CP486_RS11645 2400319..2401665 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
CP486_RS11655 2402136..2402453 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CP486_RS11660 2402450..2402665 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
CP486_RS11665 2402920..2403978 + 1059 WP_003411129.1 hypothetical protein -
CP486_RS11670 2404108..2404464 - 357 WP_003411130.1 hypothetical protein -
CP486_RS11675 2404559..2405341 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
CP486_RS11680 2405609..2405899 - 291 WP_003900476.1 YggT family protein -
CP486_RS11685 2406061..2406717 - 657 WP_003411133.1 cell division protein SepF -
CP486_RS11690 2406783..2407559 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T85169 WP_003411124.1 NZ_CP023630:c2402453-2402136 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T85169 NZ_CP023630:c2402453-2402136 [Mycobacterium tuberculosis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT85169 WP_003411127.1 NZ_CP023630:c2402665-2402450 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT85169 NZ_CP023630:c2402665-2402450 [Mycobacterium tuberculosis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References