Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 703188..703831 Replicon chromosome
Accession NZ_CP023630
Organism Mycobacterium tuberculosis strain MDRMA2441

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag CP486_RS03255 Protein ID WP_003403187.1
Coordinates 703430..703831 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag CP486_RS03250 Protein ID WP_003403184.1
Coordinates 703188..703433 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP486_RS03215 698468..698998 - 531 WP_003917320.1 two component system sensor kinase HK2 -
CP486_RS03220 698982..699677 - 696 WP_003918099.1 two-component system response regulator TcrA -
CP486_RS03225 699800..700111 + 312 WP_003403164.1 hypothetical protein -
CP486_RS03230 700183..701133 + 951 WP_003900184.1 DUF1259 domain-containing protein -
CP486_RS03235 701374..701958 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
CP486_RS03240 701960..702670 + 711 Protein_626 transposase -
CP486_RS03245 702673..703143 + 471 WP_003898523.1 hypothetical protein -
CP486_RS03250 703188..703433 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
CP486_RS03255 703430..703831 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
CP486_RS21475 704219..704386 - 168 WP_077385191.1 DUF3800 domain-containing protein -
CP486_RS21480 704419..704616 - 198 WP_003403191.1 hypothetical protein -
CP486_RS03275 704696..705853 - 1158 WP_003898524.1 hypothetical protein -
CP486_RS03280 705905..706126 - 222 WP_003898525.1 DUF4926 domain-containing protein -
CP486_RS03285 706268..706873 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T85137 WP_003403187.1 NZ_CP023630:703430-703831 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T85137 NZ_CP023630:703430-703831 [Mycobacterium tuberculosis]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT85137 WP_003403184.1 NZ_CP023630:703188-703433 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT85137 NZ_CP023630:703188-703433 [Mycobacterium tuberculosis]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References