85127

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 3826101..3826786 Replicon chromosome
Accession NZ_CP023629
Organism Mycobacterium tuberculosis strain MDRMA2260

Toxin (Protein)


Gene name vapC Uniprot ID G0TIR9
Locus tag CP485_RS18650 Protein ID WP_003417998.1
Coordinates 3826376..3826786 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CP485_RS18645 Protein ID WP_003912220.1
Coordinates 3826101..3826379 (+) Length 93 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP485_RS18625 3822090..3823691 - 1602 WP_003417969.1 FAD/NAD(P)-binding protein -
CP485_RS18630 3823708..3824412 - 705 WP_003417980.1 dTDP-4-amino-4,6-dideoxyglucose formyltransferase -
CP485_RS18635 3824530..3825096 - 567 WP_003417984.1 TetR/AcrR family transcriptional regulator -
CP485_RS18640 3825158..3826045 + 888 WP_003900050.1 alpha-ketoglutarate-dependent sulfate ester dioxygenase -
CP485_RS18645 3826101..3826379 + 279 WP_003912220.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CP485_RS18650 3826376..3826786 + 411 WP_003417998.1 type II toxin-antitoxin system VapC family toxin Toxin
CP485_RS18655 3826819..3828555 - 1737 WP_003418002.1 cholesterol oxidase -
CP485_RS18660 3828611..3829738 - 1128 WP_003418005.1 GuaB3 family IMP dehydrogenase-related protein -
CP485_RS18665 3829758..3831347 - 1590 WP_003900682.1 IMP dehydrogenase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-118)

Antitoxin

(3-54)


Sequences


Toxin        


Download         Length: 137 a.a.        Molecular weight: 14695.84 Da        Isoelectric Point: 5.1784

>T85127 WP_003417998.1 NZ_CP023629:3826376-3826786 [Mycobacterium tuberculosis]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVELMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Download         Length: 411 bp

>T85127 NZ_CP023629:3826376-3826786 [Mycobacterium tuberculosis]
GTGATCTATATGGACACCTCGGCCCTGACTAAGCTGCTCATCTCCGAGCCCGAGACGACCGAACTGCGGACATGGCTGAC
CGCGCAAAGCGGCCAGGGCGAGGACGCGGCGACAAGCACCCTTGGCCGGGTCGAGTTGATGAGAGTCGTTGCCCGATACG
GACAACCAGGCCAAACTGAGCGTGCGCGTTACCTACTCGACGGGCTCGACATCCTCCCGCTCACCGAACCGGTGATCGGT
CTAGCTGAAACGATCGGACCGGCCACCCTACGTTCTCTCGACGCGATTCACCTCGCGGCCGCAGCCCAGATCAAGCGGGA
ACTGACAGCCTTCGTCACCTACGACCACCGATTGTTGAGCGGATGCCGTGAGGTCGGCTTCGTCACCGCCTCACCCGGCG
CAGTCCGGTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10280.75 Da        Isoelectric Point: 10.1819

>AT85127 WP_003912220.1 NZ_CP023629:3826101-3826379 [Mycobacterium tuberculosis]
VEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEPARGRKRT
LSDVLNEMRDEQ

Download         Length: 279 bp

>AT85127 NZ_CP023629:3826101-3826379 [Mycobacterium tuberculosis]
GTGGAGGCAATCGGAATCCGAGAACTAAGACAGCACGCATCGCGATACCTCGCCCGGGTTGAAGCCGGCGAGGAACTTGG
CGTCACCAACAAAGGAAGACTTGTGGCCCGACTCATCCCGGTGCAGGCCGCGGAGCGTTCTCGCGAAGCCCTGATTGAAT
CAGGTGTCCTGATTCCGGCTCGTCGTCCACAAAACCTTCTCGACGTCACCGCCGAACCGGCGCGCGGCCGCAAGCGCACC
CTGTCCGATGTTCTCAACGAAATGCGCGACGAGCAGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TIR9


Antitoxin

Source ID Structure

References