85095

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1764649..1765262 Replicon chromosome
Accession NZ_CP023629
Organism Mycobacterium tuberculosis strain MDRMA2260

Toxin (Protein)


Gene name vapC Uniprot ID P64880
Locus tag CP485_RS08545 Protein ID WP_003407786.1
Coordinates 1764858..1765262 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8UJ46
Locus tag CP485_RS08540 Protein ID WP_009935474.1
Coordinates 1764649..1764852 (+) Length 68 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP485_RS08510 1760054..1760434 + 381 WP_003407768.1 fumarate reductase subunit C -
CP485_RS08515 1760431..1760808 + 378 WP_003407771.1 fumarate reductase subunit FrdD -
CP485_RS08520 1760876..1761484 + 609 WP_003407773.1 TetR/AcrR family transcriptional regulator -
CP485_RS08525 1761668..1762816 + 1149 Protein_1613 MMPL family transporter -
CP485_RS08530 1762826..1763272 + 447 WP_003407780.1 F420H(2)-dependent quinone reductase -
CP485_RS08535 1763307..1764596 + 1290 WP_003407781.1 threonine ammonia-lyase -
CP485_RS08540 1764649..1764852 + 204 WP_009935474.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
CP485_RS08545 1764858..1765262 + 405 WP_003407786.1 type II toxin-antitoxin system toxin ribonuclease VapC11 Toxin
CP485_RS08550 1765279..1767021 - 1743 WP_096875432.1 malto-oligosyltrehalose trehalohydrolase -
CP485_RS08555 1767014..1769311 - 2298 WP_003407790.1 malto-oligosyltrehalose synthase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-124)

Antitoxin

(2-44)


Sequences


Toxin        


Download         Length: 135 a.a.        Molecular weight: 14650.76 Da        Isoelectric Point: 5.6587

>T85095 WP_003407786.1 NZ_CP023629:1764858-1765262 [Mycobacterium tuberculosis]
MILIDTSAWVEYFRATGSIAAVEVRRLLSEEAARIAMCEPIAMEILSGALDDNTHTTLERLVNGLPSLNVDDAIDFRAAA
GIYRAARRAGETVRSINDCLIAALAIRHGARIVHRDADFDVIARITNLQAASFR

Download         Length: 405 bp

>T85095 NZ_CP023629:1764858-1765262 [Mycobacterium tuberculosis]
ATGATCCTCATCGACACATCGGCCTGGGTGGAGTACTTCCGTGCCACCGGATCAATCGCCGCTGTCGAAGTACGCCGGCT
GCTGTCCGAAGAAGCAGCGCGAATCGCTATGTGTGAGCCCATTGCGATGGAAATCTTGAGTGGCGCGCTCGACGACAACA
CCCACACGACGCTAGAGCGGCTCGTGAATGGCTTGCCGTCGTTGAACGTTGATGACGCGATTGACTTTCGTGCTGCCGCG
GGTATCTATCGCGCCGCCCGGCGCGCCGGCGAAACGGTTCGAAGCATCAACGACTGCCTCATAGCGGCGCTCGCGATCCG
CCACGGTGCGCGTATCGTCCACCGTGACGCCGACTTTGATGTGATTGCCCGGATTACCAACCTGCAGGCCGCATCGTTTC
GGTGA

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7501.48 Da        Isoelectric Point: 4.3951

>AT85095 WP_009935474.1 NZ_CP023629:1764649-1764852 [Mycobacterium tuberculosis]
MSRTNIDIDDELAAEVMRRFGLTTKRAAVDLALRRLVGSPLSREFLLGLEGVGWEGDLDDLRSDRPD

Download         Length: 204 bp

>AT85095 NZ_CP023629:1764649-1764852 [Mycobacterium tuberculosis]
ATGTCGCGCACCAACATCGACATCGATGACGAACTTGCCGCCGAGGTCATGCGCAGGTTCGGTCTGACCACCAAGAGGGC
GGCGGTCGACCTTGCCCTACGACGGTTGGTCGGGTCGCCGTTGAGCCGTGAGTTTCTGCTCGGGCTGGAAGGCGTCGGCT
GGGAAGGCGACCTGGATGACTTGCGAAGCGATCGCCCAGACTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6A7V


Antitoxin

Source ID Structure
AlphaFold DB A0A0E8UJ46

References