Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3770470..3770999 Replicon chromosome
Accession NZ_CP023627
Organism Mycobacterium tuberculosis strain MDRMA2019

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag CP483_RS18385 Protein ID WP_003417760.1
Coordinates 3770742..3770999 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag CP483_RS18380 Protein ID WP_003417757.1
Coordinates 3770470..3770745 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP483_RS21960 3767268..3768705 - 1438 Protein_3469 FAD-binding oxidoreductase -
CP483_RS18365 3768808..3769197 + 390 WP_003417745.1 DUF732 domain-containing protein -
CP483_RS18370 3769211..3769504 - 294 WP_003417749.1 DUF3017 domain-containing protein -
CP483_RS18375 3769501..3770346 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
CP483_RS18380 3770470..3770745 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
CP483_RS18385 3770742..3770999 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
CP483_RS18390 3771041..3772231 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
CP483_RS18395 3772348..3772716 + 369 WP_003417765.1 FHA domain-containing protein -
CP483_RS18400 3772713..3773264 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
CP483_RS18405 3773271..3773852 - 582 WP_003417769.1 ATP/GTP-binding protein -
CP483_RS18410 3773833..3774201 - 369 WP_003417772.1 DUF742 domain-containing protein -
CP483_RS18415 3774179..3774571 - 393 WP_003417776.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T85003 WP_003417760.1 NZ_CP023627:3770742-3770999 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T85003 NZ_CP023627:3770742-3770999 [Mycobacterium tuberculosis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT85003 WP_003417757.1 NZ_CP023627:3770470-3770745 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT85003 NZ_CP023627:3770470-3770745 [Mycobacterium tuberculosis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References