Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2401922..2402451 Replicon chromosome
Accession NZ_CP023627
Organism Mycobacterium tuberculosis strain MDRMA2019

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag CP483_RS11645 Protein ID WP_003411124.1
Coordinates 2401922..2402239 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag CP483_RS11650 Protein ID WP_003411127.1
Coordinates 2402236..2402451 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP483_RS11615 2397112..2398188 + 1077 WP_003411110.1 hypothetical protein -
CP483_RS11620 2398185..2398466 + 282 WP_003411112.1 hypothetical protein -
CP483_RS11625 2398502..2399575 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
CP483_RS11630 2399580..2400110 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
CP483_RS11635 2400158..2401504 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
CP483_RS11645 2401922..2402239 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CP483_RS11650 2402236..2402451 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
CP483_RS11655 2402706..2403764 + 1059 WP_003411129.1 hypothetical protein -
CP483_RS11660 2403894..2404250 - 357 WP_003411130.1 hypothetical protein -
CP483_RS11665 2404345..2405127 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
CP483_RS11670 2405395..2405685 - 291 WP_003900476.1 YggT family protein -
CP483_RS11675 2405847..2406503 - 657 WP_003411133.1 cell division protein SepF -
CP483_RS11680 2406569..2407345 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T84986 WP_003411124.1 NZ_CP023627:c2402239-2401922 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T84986 NZ_CP023627:c2402239-2401922 [Mycobacterium tuberculosis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT84986 WP_003411127.1 NZ_CP023627:c2402451-2402236 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT84986 NZ_CP023627:c2402451-2402236 [Mycobacterium tuberculosis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References