Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2203419..2203963 | Replicon | chromosome |
| Accession | NZ_CP023626 | ||
| Organism | Mycobacterium tuberculosis strain MDRMA1565 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | CP482_RS10635 | Protein ID | WP_003409896.1 |
| Coordinates | 2203419..2203715 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | CP482_RS10640 | Protein ID | WP_003409899.1 |
| Coordinates | 2203712..2203963 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CP482_RS10580 | 2198452..2198802 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| CP482_RS10585 | 2198813..2199715 | - | 903 | WP_003899097.1 | hypothetical protein | - |
| CP482_RS10590 | 2199736..2199927 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| CP482_RS10595 | 2199928..2200224 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| CP482_RS10600 | 2200464..2200679 | + | 216 | WP_003409878.1 | antitoxin | - |
| CP482_RS10605 | 2200676..2200987 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| CP482_RS21810 | 2200961..2201482 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| CP482_RS10615 | 2201457..2201834 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| CP482_RS10620 | 2201876..2202325 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| CP482_RS10625 | 2202322..2202867 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| CP482_RS10630 | 2202756..2203370 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| CP482_RS10635 | 2203419..2203715 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| CP482_RS10640 | 2203712..2203963 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| CP482_RS10645 | 2203950..2204444 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| CP482_RS10650 | 2204604..2205011 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| CP482_RS10655 | 2205015..2205287 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| CP482_RS10660 | 2205320..2206540 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| CP482_RS10675 | 2207439..2208236 | + | 798 | WP_003899101.1 | ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T84918 WP_003409896.1 NZ_CP023626:c2203715-2203419 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T84918 NZ_CP023626:c2203715-2203419 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT84918 WP_003409899.1 NZ_CP023626:c2203963-2203712 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT84918 NZ_CP023626:c2203963-2203712 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |