84883

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3770663..3771192 Replicon chromosome
Accession NZ_CP023625
Organism Mycobacterium tuberculosis strain MDRMA863

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag CP481_RS18385 Protein ID WP_003417760.1
Coordinates 3770935..3771192 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag CP481_RS18380 Protein ID WP_003417757.1
Coordinates 3770663..3770938 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP481_RS21910 3767461..3768898 - 1438 Protein_3468 FAD-binding oxidoreductase -
CP481_RS18365 3769001..3769390 + 390 WP_003417745.1 DUF732 domain-containing protein -
CP481_RS18370 3769404..3769697 - 294 WP_003417749.1 DUF3017 domain-containing protein -
CP481_RS18375 3769694..3770539 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
CP481_RS18380 3770663..3770938 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
CP481_RS18385 3770935..3771192 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
CP481_RS18390 3771234..3772424 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
CP481_RS18395 3772541..3772909 + 369 WP_003417765.1 FHA domain-containing protein -
CP481_RS18400 3772906..3773457 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
CP481_RS18405 3773464..3774045 - 582 WP_003417769.1 ATP/GTP-binding protein -
CP481_RS18410 3774026..3774394 - 369 WP_003417772.1 DUF742 domain-containing protein -
CP481_RS18415 3774372..3774764 - 393 WP_003417776.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T84883 WP_003417760.1 NZ_CP023625:3770935-3771192 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T84883 NZ_CP023625:3770935-3771192 [Mycobacterium tuberculosis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT84883 WP_003417757.1 NZ_CP023625:3770663-3770938 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT84883 NZ_CP023625:3770663-3770938 [Mycobacterium tuberculosis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
AlphaFold DB G0TI94

References