Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2203548..2204092 | Replicon | chromosome |
| Accession | NZ_CP023624 | ||
| Organism | Mycobacterium tuberculosis strain MDRMA701 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | CP480_RS10650 | Protein ID | WP_003409896.1 |
| Coordinates | 2203548..2203844 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | CP480_RS10655 | Protein ID | WP_003409899.1 |
| Coordinates | 2203841..2204092 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CP480_RS10595 | 2198581..2198931 | - | 351 | WP_003899096.1 | hypothetical protein | - |
| CP480_RS10600 | 2198942..2199844 | - | 903 | WP_003899097.1 | hypothetical protein | - |
| CP480_RS10605 | 2199865..2200056 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| CP480_RS10610 | 2200057..2200353 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| CP480_RS10615 | 2200593..2200808 | + | 216 | WP_003409878.1 | antitoxin | - |
| CP480_RS10620 | 2200805..2201116 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| CP480_RS21830 | 2201090..2201611 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| CP480_RS10630 | 2201586..2201963 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| CP480_RS10635 | 2202005..2202454 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| CP480_RS10640 | 2202451..2202996 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| CP480_RS10645 | 2202885..2203499 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| CP480_RS10650 | 2203548..2203844 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| CP480_RS10655 | 2203841..2204092 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| CP480_RS10660 | 2204079..2204573 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| CP480_RS10665 | 2204733..2205140 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| CP480_RS10670 | 2205144..2205416 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| CP480_RS10675 | 2205449..2206669 | - | 1221 | WP_009937688.1 | TetR family transcriptional regulator Mce3R | - |
| CP480_RS10690 | 2207568..2208365 | + | 798 | WP_003899101.1 | ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T84798 WP_003409896.1 NZ_CP023624:c2203844-2203548 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T84798 NZ_CP023624:c2203844-2203548 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT84798 WP_003409899.1 NZ_CP023624:c2204092-2203841 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT84798 NZ_CP023624:c2204092-2203841 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |