84762

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3770579..3771108 Replicon chromosome
Accession NZ_CP023623
Organism Mycobacterium tuberculosis strain MDRMA203

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag CP479_RS18375 Protein ID WP_003417760.1
Coordinates 3770851..3771108 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag CP479_RS18370 Protein ID WP_003417757.1
Coordinates 3770579..3770854 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP479_RS21920 3767377..3768814 - 1438 Protein_3468 FAD-binding oxidoreductase -
CP479_RS18355 3768917..3769306 + 390 WP_003417745.1 DUF732 domain-containing protein -
CP479_RS18360 3769320..3769613 - 294 WP_003417749.1 DUF3017 domain-containing protein -
CP479_RS18365 3769610..3770455 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
CP479_RS18370 3770579..3770854 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
CP479_RS18375 3770851..3771108 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
CP479_RS18380 3771150..3772340 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
CP479_RS18385 3772457..3772825 + 369 WP_003417765.1 FHA domain-containing protein -
CP479_RS18390 3772822..3773373 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
CP479_RS18395 3773380..3773961 - 582 WP_003417769.1 ATP/GTP-binding protein -
CP479_RS18400 3773942..3774310 - 369 WP_003417772.1 DUF742 domain-containing protein -
CP479_RS18405 3774288..3774680 - 393 WP_003417776.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T84762 WP_003417760.1 NZ_CP023623:3770851-3771108 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T84762 NZ_CP023623:3770851-3771108 [Mycobacterium tuberculosis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT84762 WP_003417757.1 NZ_CP023623:3770579-3770854 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT84762 NZ_CP023623:3770579-3770854 [Mycobacterium tuberculosis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
AlphaFold DB G0TI94

References