Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2402105..2402634 Replicon chromosome
Accession NZ_CP023623
Organism Mycobacterium tuberculosis strain MDRMA203

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag CP479_RS11635 Protein ID WP_003411124.1
Coordinates 2402105..2402422 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag CP479_RS11640 Protein ID WP_003411127.1
Coordinates 2402419..2402634 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP479_RS11605 2397242..2398318 + 1077 WP_003411110.1 hypothetical protein -
CP479_RS11610 2398315..2398596 + 282 WP_003411112.1 hypothetical protein -
CP479_RS11615 2398632..2399705 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
CP479_RS11620 2399710..2400240 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
CP479_RS11625 2400288..2401634 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
CP479_RS11635 2402105..2402422 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CP479_RS11640 2402419..2402634 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
CP479_RS11645 2402889..2403947 + 1059 WP_003411129.1 hypothetical protein -
CP479_RS11650 2404077..2404433 - 357 WP_003411130.1 hypothetical protein -
CP479_RS11655 2404528..2405310 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
CP479_RS11660 2405578..2405868 - 291 WP_003900476.1 YggT family protein -
CP479_RS11665 2406030..2406686 - 657 WP_015456354.1 cell division protein SepF -
CP479_RS11670 2406752..2407528 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T84745 WP_003411124.1 NZ_CP023623:c2402422-2402105 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T84745 NZ_CP023623:c2402422-2402105 [Mycobacterium tuberculosis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT84745 WP_003411127.1 NZ_CP023623:c2402634-2402419 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT84745 NZ_CP023623:c2402634-2402419 [Mycobacterium tuberculosis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References