84626

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2867954..2868663 Replicon chromosome
Accession NZ_CP023621
Organism Mycobacterium tuberculosis strain LN2900

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag CP477_RS13945 Protein ID WP_003413164.1
Coordinates 2867954..2868367 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag CP477_RS13950 Protein ID WP_003413167.1
Coordinates 2868406..2868663 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP477_RS13910 2863007..2864212 - 1206 WP_003413027.1 chorismate synthase -
CP477_RS13915 2864320..2864634 + 315 WP_009937839.1 hypothetical protein -
CP477_RS13920 2864930..2866141 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
CP477_RS13930 2866268..2866927 + 660 WP_003900846.1 LppA family lipoprotein -
CP477_RS13935 2866924..2867586 + 663 WP_003900848.1 hypothetical protein -
CP477_RS13940 2867583..2867861 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
CP477_RS13945 2867954..2868367 + 414 WP_003413164.1 PIN domain nuclease Toxin
CP477_RS13950 2868406..2868663 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
CP477_RS13955 2868660..2869037 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
CP477_RS13960 2869053..2869427 - 375 WP_003413177.1 hypothetical protein -
CP477_RS13965 2869527..2869922 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
CP477_RS13970 2869919..2870164 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
CP477_RS13980 2870575..2870994 - 420 WP_003413190.1 A24 family peptidase -
CP477_RS13985 2871006..2871815 - 810 WP_003413193.1 shikimate dehydrogenase -
CP477_RS13990 2871812..2873065 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
CP477_RS13995 2873058..2873570 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T84626 WP_003413164.1 NZ_CP023621:2867954-2868367 [Mycobacterium tuberculosis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T84626 NZ_CP023621:2867954-2868367 [Mycobacterium tuberculosis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT84626 WP_003413167.1 NZ_CP023621:2868406-2868663 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT84626 NZ_CP023621:2868406-2868663 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ26

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References