84389

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3110119..3110689 Replicon chromosome
Accession NZ_CP023617
Organism Mycobacterium tuberculosis strain LN3672

Toxin (Protein)


Gene name mazF Uniprot ID P71650
Locus tag CP473_RS15320 Protein ID WP_003414166.1
Coordinates 3110119..3110475 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL61
Locus tag CP473_RS15325 Protein ID WP_003901465.1
Coordinates 3110459..3110689 (-) Length 77 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP473_RS15300 3105571..3107259 - 1689 WP_003414155.1 alpha/beta hydrolase family protein -
CP473_RS15305 3107263..3107589 - 327 WP_003414157.1 hypothetical protein -
CP473_RS15310 3107762..3108349 + 588 WP_023641719.1 DUF3558 family protein -
CP473_RS15315 3108368..3110017 + 1650 WP_003899485.1 CocE/NonD family hydrolase -
CP473_RS15320 3110119..3110475 - 357 WP_003414166.1 type II toxin-antitoxin system toxin endoribonuclease MazF9 Toxin
CP473_RS15325 3110459..3110689 - 231 WP_003901465.1 antitoxin MazE Antitoxin
CP473_RS15330 3110732..3111775 - 1044 WP_003414172.1 DUF2293 domain-containing protein -
CP473_RS15335 3111966..3112241 + 276 WP_003911993.1 DUF1778 domain-containing protein -
CP473_RS21540 3112417..3112671 - 255 WP_003917684.1 hypothetical protein -
CP473_RS15345 3112819..3113223 + 405 WP_009938577.1 hypothetical protein -
CP473_RS15350 3113220..3113411 + 192 WP_003414184.1 hypothetical protein -
CP473_RS15355 3113475..3114764 + 1290 Protein_2901 transposase family protein -
CP473_RS15360 3114998..3115255 + 258 WP_003899489.1 hypothetical protein -
CP473_RS15365 3115360..3115671 + 312 WP_003414190.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-113)

Antitoxin

(3-29)


Sequences


Toxin        


Download         Length: 119 a.a.        Molecular weight: 12858.73 Da        Isoelectric Point: 9.1962

>T84389 WP_003414166.1 NZ_CP023617:c3110475-3110119 [Mycobacterium tuberculosis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS

Download         Length: 357 bp

>T84389 NZ_CP023617:c3110475-3110119 [Mycobacterium tuberculosis]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8231.01 Da        Isoelectric Point: 4.1809

>AT84389 WP_003901465.1 NZ_CP023617:c3110689-3110459 [Mycobacterium tuberculosis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR

Download         Length: 231 bp

>AT84389 NZ_CP023617:c3110689-3110459 [Mycobacterium tuberculosis]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6L2A
PDB 5HJZ
PDB 6KYT
PDB 6L29
PDB 7DU5
PDB 6KYS


Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FBW3

References