Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
Location | 3110119..3110689 | Replicon | chromosome |
Accession | NZ_CP023617 | ||
Organism | Mycobacterium tuberculosis strain LN3672 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | P71650 |
Locus tag | CP473_RS15320 | Protein ID | WP_003414166.1 |
Coordinates | 3110119..3110475 (-) | Length | 119 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | P0CL61 |
Locus tag | CP473_RS15325 | Protein ID | WP_003901465.1 |
Coordinates | 3110459..3110689 (-) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CP473_RS15300 | 3105571..3107259 | - | 1689 | WP_003414155.1 | alpha/beta hydrolase family protein | - |
CP473_RS15305 | 3107263..3107589 | - | 327 | WP_003414157.1 | hypothetical protein | - |
CP473_RS15310 | 3107762..3108349 | + | 588 | WP_023641719.1 | DUF3558 family protein | - |
CP473_RS15315 | 3108368..3110017 | + | 1650 | WP_003899485.1 | CocE/NonD family hydrolase | - |
CP473_RS15320 | 3110119..3110475 | - | 357 | WP_003414166.1 | type II toxin-antitoxin system toxin endoribonuclease MazF9 | Toxin |
CP473_RS15325 | 3110459..3110689 | - | 231 | WP_003901465.1 | antitoxin MazE | Antitoxin |
CP473_RS15330 | 3110732..3111775 | - | 1044 | WP_003414172.1 | DUF2293 domain-containing protein | - |
CP473_RS15335 | 3111966..3112241 | + | 276 | WP_003911993.1 | DUF1778 domain-containing protein | - |
CP473_RS21540 | 3112417..3112671 | - | 255 | WP_003917684.1 | hypothetical protein | - |
CP473_RS15345 | 3112819..3113223 | + | 405 | WP_009938577.1 | hypothetical protein | - |
CP473_RS15350 | 3113220..3113411 | + | 192 | WP_003414184.1 | hypothetical protein | - |
CP473_RS15355 | 3113475..3114764 | + | 1290 | Protein_2901 | transposase family protein | - |
CP473_RS15360 | 3114998..3115255 | + | 258 | WP_003899489.1 | hypothetical protein | - |
CP473_RS15365 | 3115360..3115671 | + | 312 | WP_003414190.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 119 a.a. Molecular weight: 12858.73 Da Isoelectric Point: 9.1962
>T84389 WP_003414166.1 NZ_CP023617:c3110475-3110119 [Mycobacterium tuberculosis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS
Download Length: 357 bp
>T84389 NZ_CP023617:c3110475-3110119 [Mycobacterium tuberculosis]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG
Antitoxin
Download Length: 77 a.a. Molecular weight: 8231.01 Da Isoelectric Point: 4.1809
>AT84389 WP_003901465.1 NZ_CP023617:c3110689-3110459 [Mycobacterium tuberculosis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR
Download Length: 231 bp
>AT84389 NZ_CP023617:c3110689-3110459 [Mycobacterium tuberculosis]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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