84382

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2868107..2868816 Replicon chromosome
Accession NZ_CP023617
Organism Mycobacterium tuberculosis strain LN3672

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag CP473_RS13945 Protein ID WP_003413164.1
Coordinates 2868107..2868520 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag CP473_RS13950 Protein ID WP_003413167.1
Coordinates 2868559..2868816 (+) Length 86 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP473_RS13910 2863160..2864365 - 1206 WP_003413027.1 chorismate synthase -
CP473_RS13915 2864473..2864787 + 315 WP_009937839.1 hypothetical protein -
CP473_RS13920 2865083..2866294 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
CP473_RS13930 2866421..2867080 + 660 WP_003900846.1 LppA family lipoprotein -
CP473_RS13935 2867077..2867739 + 663 WP_003900848.1 hypothetical protein -
CP473_RS13940 2867736..2868014 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
CP473_RS13945 2868107..2868520 + 414 WP_003413164.1 PIN domain nuclease Toxin
CP473_RS13950 2868559..2868816 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
CP473_RS13955 2868813..2869190 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
CP473_RS13960 2869206..2869580 - 375 WP_003413177.1 hypothetical protein -
CP473_RS13965 2869680..2870075 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
CP473_RS13970 2870072..2870317 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
CP473_RS13980 2870728..2871147 - 420 WP_003413190.1 A24 family peptidase -
CP473_RS13985 2871159..2871968 - 810 WP_003413193.1 shikimate dehydrogenase -
CP473_RS13990 2871965..2873218 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
CP473_RS13995 2873211..2873723 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-122)

Antitoxin

(2-38)


Sequences


Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T84382 WP_003413164.1 NZ_CP023617:2868107-2868520 [Mycobacterium tuberculosis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T84382 NZ_CP023617:2868107-2868520 [Mycobacterium tuberculosis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT84382 WP_003413167.1 NZ_CP023617:2868559-2868816 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT84382 NZ_CP023617:2868559-2868816 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TQ26


Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References