Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2203638..2204182 Replicon chromosome
Accession NZ_CP023617
Organism Mycobacterium tuberculosis strain LN3672

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag CP473_RS10640 Protein ID WP_003409896.1
Coordinates 2203638..2203934 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag CP473_RS10645 Protein ID WP_003409899.1
Coordinates 2203931..2204182 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP473_RS10585 2198671..2199021 - 351 WP_003899096.1 hypothetical protein -
CP473_RS10590 2199032..2199934 - 903 WP_003899097.1 hypothetical protein -
CP473_RS10595 2199955..2200146 - 192 WP_003409876.1 hypothetical protein -
CP473_RS10600 2200147..2200443 - 297 WP_003409877.1 hypothetical protein -
CP473_RS10605 2200683..2200898 + 216 WP_003409878.1 antitoxin -
CP473_RS10610 2200895..2201206 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
CP473_RS21815 2201180..2201701 - 522 WP_003904745.1 hypothetical protein -
CP473_RS10620 2201676..2202053 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
CP473_RS10625 2202095..2202544 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
CP473_RS10630 2202541..2203086 + 546 WP_003409891.1 SecB-like chaperone -
CP473_RS10635 2202975..2203589 - 615 WP_003901296.1 hypothetical protein -
CP473_RS10640 2203638..2203934 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CP473_RS10645 2203931..2204182 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
CP473_RS10650 2204169..2204663 + 495 WP_003899099.1 hypothetical protein -
CP473_RS10655 2204823..2205230 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
CP473_RS10660 2205234..2205506 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
CP473_RS10665 2205539..2206759 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
CP473_RS10680 2207658..2208455 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T84371 WP_003409896.1 NZ_CP023617:c2203934-2203638 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T84371 NZ_CP023617:c2203934-2203638 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT84371 WP_003409899.1 NZ_CP023617:c2204182-2203931 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT84371 NZ_CP023617:c2204182-2203931 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References