Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2203658..2204202 Replicon chromosome
Accession NZ_CP023616
Organism Mycobacterium tuberculosis strain LN3668

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag CP472_RS10635 Protein ID WP_003409896.1
Coordinates 2203658..2203954 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag CP472_RS10640 Protein ID WP_003409899.1
Coordinates 2203951..2204202 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP472_RS10580 2198691..2199041 - 351 WP_003899096.1 hypothetical protein -
CP472_RS10585 2199052..2199954 - 903 WP_003899097.1 hypothetical protein -
CP472_RS10590 2199975..2200166 - 192 WP_003409876.1 hypothetical protein -
CP472_RS10595 2200167..2200463 - 297 WP_003409877.1 hypothetical protein -
CP472_RS10600 2200703..2200918 + 216 WP_003409878.1 antitoxin -
CP472_RS10605 2200915..2201226 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
CP472_RS21805 2201200..2201721 - 522 WP_003904745.1 hypothetical protein -
CP472_RS10615 2201696..2202073 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
CP472_RS10620 2202115..2202564 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
CP472_RS10625 2202561..2203106 + 546 WP_003409891.1 SecB-like chaperone -
CP472_RS10630 2202995..2203609 - 615 WP_003901296.1 hypothetical protein -
CP472_RS10635 2203658..2203954 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CP472_RS10640 2203951..2204202 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
CP472_RS10645 2204189..2204683 + 495 WP_003899099.1 hypothetical protein -
CP472_RS10650 2204843..2205250 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
CP472_RS10655 2205254..2205526 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
CP472_RS10660 2205559..2206779 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
CP472_RS10675 2207678..2208475 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T84310 WP_003409896.1 NZ_CP023616:c2203954-2203658 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T84310 NZ_CP023616:c2203954-2203658 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT84310 WP_003409899.1 NZ_CP023616:c2204202-2203951 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT84310 NZ_CP023616:c2204202-2203951 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References