Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2203596..2204140 Replicon chromosome
Accession NZ_CP023614
Organism Mycobacterium tuberculosis strain LN3588

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag CP470_RS10650 Protein ID WP_003409896.1
Coordinates 2203596..2203892 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag CP470_RS10655 Protein ID WP_003409899.1
Coordinates 2203889..2204140 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP470_RS10595 2198629..2198979 - 351 WP_003899096.1 hypothetical protein -
CP470_RS10600 2198990..2199892 - 903 WP_003899097.1 hypothetical protein -
CP470_RS10605 2199913..2200104 - 192 WP_003409876.1 hypothetical protein -
CP470_RS10610 2200105..2200401 - 297 WP_003409877.1 hypothetical protein -
CP470_RS10615 2200641..2200856 + 216 WP_003409878.1 antitoxin -
CP470_RS10620 2200853..2201164 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
CP470_RS21835 2201138..2201659 - 522 WP_003904745.1 hypothetical protein -
CP470_RS10630 2201634..2202011 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
CP470_RS10635 2202053..2202502 + 450 WP_096865287.1 type II toxin-antitoxin system antitoxin HigA -
CP470_RS10640 2202499..2203044 + 546 WP_003409891.1 SecB-like chaperone -
CP470_RS10645 2202933..2203547 - 615 WP_003901296.1 hypothetical protein -
CP470_RS10650 2203596..2203892 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CP470_RS10655 2203889..2204140 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
CP470_RS10660 2204127..2204621 + 495 WP_003899099.1 hypothetical protein -
CP470_RS10665 2204781..2205188 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
CP470_RS10670 2205192..2205464 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
CP470_RS10675 2205497..2206717 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
CP470_RS10690 2207616..2208413 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-93)

Antitoxin

(2-80)


Sequences


Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T84188 WP_003409896.1 NZ_CP023614:c2203892-2203596 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T84188 NZ_CP023614:c2203892-2203596 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT84188 WP_003409899.1 NZ_CP023614:c2204140-2203889 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT84188 NZ_CP023614:c2204140-2203889 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TLU9


Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References