Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1014601..1015220 Replicon chromosome
Accession NZ_CP023614
Organism Mycobacterium tuberculosis strain LN3588

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag CP470_RS04955 Protein ID WP_003404726.1
Coordinates 1014786..1015220 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ06
Locus tag CP470_RS04950 Protein ID WP_003898641.1
Coordinates 1014601..1014780 (+) Length 60 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP470_RS04940 1010074..1011654 + 1581 WP_003909313.1 serine hydrolase -
CP470_RS04945 1011651..1014044 + 2394 WP_003898639.1 cation-translocating P-type ATPase -
CP470_RS21715 1014317..1014475 + 159 WP_003404720.1 hypothetical protein -
CP470_RS04950 1014601..1014780 + 180 WP_003898641.1 antitoxin Antitoxin
CP470_RS04955 1014786..1015220 + 435 WP_003404726.1 SRPBCC family protein Toxin
CP470_RS04960 1015318..1016091 + 774 WP_003404735.1 VOC family protein -
CP470_RS04965 1016156..1016605 + 450 WP_003404738.1 hypothetical protein -
CP470_RS04970 1016740..1016970 - 231 WP_003898642.1 hypothetical protein -
CP470_RS04975 1017137..1018645 - 1509 WP_003404742.1 carotenoid oxygenase family protein -
CP470_RS04980 1018647..1019885 - 1239 WP_003404744.1 acetyl-CoA acetyltransferase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-142)

Antitoxin

(4-50)


Sequences


Toxin        


Download         Length: 145 a.a.        Molecular weight: 15754.47 Da        Isoelectric Point: 9.7977

>T84173 WP_003404726.1 NZ_CP023614:1014786-1015220 [Mycobacterium tuberculosis]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Download         Length: 435 bp

>T84173 NZ_CP023614:1014786-1015220 [Mycobacterium tuberculosis]
ATGGCGAAACTGTCCGGATCCATCGACGTACCGCTGCCACCGGAGGAAGCCTGGATGCACGCCTCCGATCTGACTCGTTA
CCGAGAGTGGCTGACCATCCACAAGGTATGGCGCAGCAAGTTGCCCGAAGTGCTCGAGAAGGGCACGGTCGTCGAGTCGT
ATGTCGAGGTCAAGGGCATGCCCAACCGGATCAAGTGGACGATCGTGCGGTACAAACCCCCGGAGGGCATGACGCTCAAC
GGCGACGGTGTGGGTGGTGTCAAAGTCAAGCTGATCGCTAAGGTAGCGCCGAAAGAGCACGGCTCCGTCGTCAGCTTCGA
TGTGCACCTCGGCGGCCCGGCCCTGCTCGGGCCGATCGGCATGATCGTCGCCGCTGCATTGCGAGCCGACATCCGCGAAT
CGCTGCAGAACTTCGTCACGGTGTTTGCCGGCTGA

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6403.07 Da        Isoelectric Point: 4.5393

>AT84173 WP_003898641.1 NZ_CP023614:1014601-1014780 [Mycobacterium tuberculosis]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLHDAASNVVGMSDQQS

Download         Length: 180 bp

>AT84173 NZ_CP023614:1014601-1014780 [Mycobacterium tuberculosis]
ATGGGAATCCTGGACAAGGTAAAGAACCTGCTGTCGCAGAACGCCGACAAGGTCGAGACGGTGATCAACAAAGCGGGCGA
ATTCGTCGACGAGCAGACGCAAGGCAATTATTCTGACGCCATCCACAAGCTGCATGACGCGGCCAGCAACGTCGTCGGCA
TGAGCGACCAGCAGAGCTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A045KDK5

References