Detailed information of TA system TA083952

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/-
• Location: 2402063..2402592
• Replicon: chromosome
• Accession: NZ_CP023610
• Organism: Mycobacterium tuberculosis strain LN317

Toxin (Protein)

• Gene name: parE
• Uniprot ID: G0TMR4
• Locus tag: CP466_RS11655
• Protein ID: WP_003411124.1
• Coordinates: 2402063..2402380 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: P9WJ74
• Locus tag: CP466_RS11660
• Protein ID: WP_003411127.1
• Coordinates: 2402377..2402592 (-)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CP466_RS11625	2397200..2398276	+	1077	WP_003411110.1	hypothetical protein	-
CP466_RS11630	2398273..2398554	+	282	WP_003411112.1	hypothetical protein	-
CP466_RS11635	2398590..2399663	+	1074	WP_003411116.1	quinone-dependent dihydroorotate dehydrogenase	-
CP466_RS11640	2399668..2400198	-	531	WP_003411119.1	YbhB/YbcL family Raf kinase inhibitor-like protein	-
CP466_RS11645	2400246..2401592	-	1347	WP_003411121.1	M20/M25/M40 family metallo-hydrolase	-
CP466_RS11655	2402063..2402380	-	318	WP_003411124.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CP466_RS11660	2402377..2402592	-	216	WP_003411127.1	antitoxin ParD2	Antitoxin
CP466_RS11665	2402847..2403905	+	1059	WP_003411129.1	hypothetical protein	-
CP466_RS11670	2404035..2404391	-	357	WP_003411130.1	hypothetical protein	-
CP466_RS11675	2404486..2405268	-	783	WP_003411131.1	cell wall synthesis protein Wag31	-
CP466_RS11680	2405536..2405826	-	291	WP_003900476.1	YggT family protein	-
CP466_RS11685	2405988..2406644	-	657	WP_003411133.1	cell division protein SepF	-
CP466_RS11690	2406710..2407486	-	777	WP_003411137.1	YggS family pyridoxal phosphate-dependent enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-92)

Antitoxin

• Conserved hypothetical protein CHP02574, addiction module (11-69)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12312.88 Da
• Isoelectric Point: 6.4831

>T83952 WP_003411124.1 NZ_CP023610:c2402380-2402063 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Nucleotide

• Length: 318 bp

>T83952 NZ_CP023610:c2402380-2402063 [Mycobacterium tuberculosis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 7880.70 Da
• Isoelectric Point: 4.4055

>AT83952 WP_003411127.1 NZ_CP023610:c2402592-2402377 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Nucleotide

• Length: 216 bp

>AT83952 NZ_CP023610:c2402592-2402377 [Mycobacterium tuberculosis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Structures

Toxin

• AlphaFold DB: G0TMR4

Antitoxin

• AlphaFold DB: A0A7U4FAJ4