Detailed information of TA system TA083813

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1384190..1384878
• Replicon: chromosome
• Accession: NZ_CP023608
• Organism: Mycobacterium tuberculosis strain LE410

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: CP464_RS06785
• Protein ID: WP_003406304.1
• Coordinates: 1384447..1384878 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: CP464_RS06780
• Protein ID: WP_003406302.1
• Coordinates: 1384190..1384450 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CP464_RS06760	1379767..1380591	+	825	WP_003900298.1	trehalose ABC transporter permease SugB	-
CP464_RS06765	1380596..1381777	+	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
CP464_RS06770	1381854..1382954	-	1101	WP_003406300.1	magnesium/cobalt transporter CorA	-
CP464_RS06775	1383125..1384114	+	990	WP_003406301.1	malate dehydrogenase	-
CP464_RS06780	1384190..1384450	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
CP464_RS06785	1384447..1384878	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
CP464_RS06790	1384901..1386589	-	1689	WP_003910308.1	PE family protein	-
CP464_RS06800	1386769..1387629	+	861	WP_003900301.1	hypothetical protein	-
CP464_RS06805	1387710..1388540	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
CP464_RS06810	1388597..1388890	-	294	WP_096874419.1	type II toxin-antitoxin system mRNA interferase RelE	-
CP464_RS06815	1388887..1389156	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T83813 WP_003406304.1 NZ_CP023608:1384447-1384878 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T83813 NZ_CP023608:1384447-1384878 [Mycobacterium tuberculosis]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT83813 WP_003406302.1 NZ_CP023608:1384190-1384450 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT83813 NZ_CP023608:1384190-1384450 [Mycobacterium tuberculosis]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6