Detailed information of TA system TA083691

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1384149..1384837
• Replicon: chromosome
• Accession: NZ_CP023606
• Organism: Mycobacterium tuberculosis strain LE103

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: CP462_RS06790
• Protein ID: WP_003406304.1
• Coordinates: 1384406..1384837 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: CP462_RS06785
• Protein ID: WP_003406302.1
• Coordinates: 1384149..1384409 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CP462_RS06765	1379726..1380550	+	825	WP_003900298.1	trehalose ABC transporter permease SugB	-
CP462_RS06770	1380555..1381736	+	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
CP462_RS06775	1381813..1382913	-	1101	WP_003406300.1	magnesium/cobalt transporter CorA	-
CP462_RS06780	1383084..1384073	+	990	WP_003406301.1	malate dehydrogenase	-
CP462_RS06785	1384149..1384409	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
CP462_RS06790	1384406..1384837	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
CP462_RS06795	1384860..1386548	-	1689	WP_003910308.1	PE family protein	-
CP462_RS06805	1386728..1387588	+	861	WP_003900301.1	hypothetical protein	-
CP462_RS06810	1387669..1388499	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
CP462_RS06815	1388556..1388849	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
CP462_RS06820	1388846..1389115	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T83691 WP_003406304.1 NZ_CP023606:1384406-1384837 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T83691 NZ_CP023606:1384406-1384837 [Mycobacterium tuberculosis]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT83691 WP_003406302.1 NZ_CP023606:1384149-1384409 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT83691 NZ_CP023606:1384149-1384409 [Mycobacterium tuberculosis]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6