Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1014542..1015161 Replicon chromosome
Accession NZ_CP023604
Organism Mycobacterium tuberculosis strain LE76

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag CP460_RS04950 Protein ID WP_003404726.1
Coordinates 1014727..1015161 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ06
Locus tag CP460_RS04945 Protein ID WP_003898641.1
Coordinates 1014542..1014721 (+) Length 60 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP460_RS04935 1010015..1011595 + 1581 WP_003909313.1 serine hydrolase -
CP460_RS04940 1011592..1013985 + 2394 WP_003898639.1 cation-translocating P-type ATPase -
CP460_RS21710 1014258..1014416 + 159 WP_003404720.1 hypothetical protein -
CP460_RS04945 1014542..1014721 + 180 WP_003898641.1 antitoxin Antitoxin
CP460_RS04950 1014727..1015161 + 435 WP_003404726.1 SRPBCC family protein Toxin
CP460_RS04955 1015259..1016032 + 774 WP_003404735.1 VOC family protein -
CP460_RS04960 1016097..1016546 + 450 WP_003404738.1 hypothetical protein -
CP460_RS04965 1016681..1016911 - 231 WP_003898642.1 hypothetical protein -
CP460_RS04970 1017078..1018586 - 1509 WP_003404742.1 carotenoid oxygenase family protein -
CP460_RS04975 1018588..1019826 - 1239 WP_003404744.1 acetyl-CoA acetyltransferase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-142)

Antitoxin

(4-50)


Sequences


Toxin        


Download         Length: 145 a.a.        Molecular weight: 15754.47 Da        Isoelectric Point: 9.7977

>T83564 WP_003404726.1 NZ_CP023604:1014727-1015161 [Mycobacterium tuberculosis]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Download         Length: 435 bp

>T83564 NZ_CP023604:1014727-1015161 [Mycobacterium tuberculosis]
ATGGCGAAACTGTCCGGATCCATCGACGTACCGCTGCCACCGGAGGAAGCCTGGATGCACGCCTCCGATCTGACTCGTTA
CCGAGAGTGGCTGACCATCCACAAGGTATGGCGCAGCAAGTTGCCCGAAGTGCTCGAGAAGGGCACGGTCGTCGAGTCGT
ATGTCGAGGTCAAGGGCATGCCCAACCGGATCAAGTGGACGATCGTGCGGTACAAACCCCCGGAGGGCATGACGCTCAAC
GGCGACGGTGTGGGTGGTGTCAAAGTCAAGCTGATCGCTAAGGTAGCGCCGAAAGAGCACGGCTCCGTCGTCAGCTTCGA
TGTGCACCTCGGCGGCCCGGCCCTGCTCGGGCCGATCGGCATGATCGTCGCCGCTGCATTGCGAGCCGACATCCGCGAAT
CGCTGCAGAACTTCGTCACGGTGTTTGCCGGCTGA

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6403.07 Da        Isoelectric Point: 4.5393

>AT83564 WP_003898641.1 NZ_CP023604:1014542-1014721 [Mycobacterium tuberculosis]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLHDAASNVVGMSDQQS

Download         Length: 180 bp

>AT83564 NZ_CP023604:1014542-1014721 [Mycobacterium tuberculosis]
ATGGGAATCCTGGACAAGGTAAAGAACCTGCTGTCGCAGAACGCCGACAAGGTCGAGACGGTGATCAACAAAGCGGGCGA
ATTCGTCGACGAGCAGACGCAAGGCAATTATTCTGACGCCATCCACAAGCTGCATGACGCGGCCAGCAACGTCGTCGGCA
TGAGCGACCAGCAGAGCTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A045KDK5

References