Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1230559..1231190 Replicon chromosome
Accession NZ_CP023601
Organism Mycobacterium tuberculosis strain CSV9577

Toxin (Protein)


Gene name mazF Uniprot ID P9WIH8
Locus tag CP457_RS06045 Protein ID WP_003898728.1
Coordinates 1230559..1230870 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TGZ7
Locus tag CP457_RS06050 Protein ID WP_003405836.1
Coordinates 1230870..1231190 (-) Length 107 a.a.

Genomic Context

CP457_RS06035CP457_RS06055CP457_RS06025CP457_RS06030CP457_RS06040CP457_RS06045CP457_RS06050CP457_RS06060CP457_RS06065CP457_RS06070CP457_RS06075
Location: 1228639..1229283 (645 bp)
Type: Others
Protein ID: WP_003915494.1
Location: 1231200..1232725 (1526 bp)
Type: Others
Protein ID: Protein_1147
Location: 1226040..1227464 (1425 bp)
Type: Others
Protein ID: WP_003405805.1
Location: 1227495..1228583 (1089 bp)
Type: Others
Protein ID: WP_003898726.1
Location: 1229290..1230447 (1158 bp)
Type: Others
Protein ID: WP_003898727.1
Location: 1230559..1230870 (312 bp)
Type: Toxin
Protein ID: WP_003898728.1
Location: 1230870..1231190 (321 bp)
Type: Antitoxin
Protein ID: WP_003405836.1
Location: 1232743..1233855 (1113 bp)
Type: Others
Protein ID: WP_003405840.1
Location: 1233865..1234122 (258 bp)
Type: Others
Protein ID: WP_003405844.1
Location: 1234112..1235359 (1248 bp)
Type: Others
Protein ID: WP_003405846.1
Location: 1235356..1235994 (639 bp)
Type: Others
Protein ID: WP_003898730.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CP457_RS060251226040..1227464-1425WP_003405805.1class II fumarate hydratase-
CP457_RS060301227495..1228583-1089WP_003898726.1class II fructose-bisphosphatase-
CP457_RS060351228639..1229283+645WP_003915494.1DUF4245 domain-containing protein-
CP457_RS060401229290..1230447-1158WP_003898727.1AI-2E family transporter-
CP457_RS060451230559..1230870-312WP_003898728.1type II toxin-antitoxin system toxin endoribonuclease MazF3Toxin
CP457_RS060501230870..1231190-321WP_003405836.1type II toxin-antitoxin system antitoxin MazE3Antitoxin
CP457_RS060551231200..1232725+1526Protein_1147carboxylesterase/lipase family protein-
CP457_RS060601232743..1233855-1113WP_003405840.13 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase-
CP457_RS060651233865..1234122-258WP_003405844.1exodeoxyribonuclease VII small subunit-
CP457_RS060701234112..1235359-1248WP_003405846.1exodeoxyribonuclease VII large subunit-
CP457_RS060751235356..1235994-639WP_003898730.1lipid droplet-associated protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11049.76 Da        Isoelectric Point: 4.9371

>T83384 WP_003898728.1 NZ_CP023601:c1230870-1230559 [Mycobacterium tuberculosis]
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNTQTIPVCDLGRQIGYL
LASQEPALAEAIGNAFDLDWVVA

Download         Length: 312 bp

>T83384 NZ_CP023601:c1230870-1230559 [Mycobacterium tuberculosis]
ATGCGACCTATCCACATCGCACAGCTTGACAAGGCTAGACCCGTCCTGATCCTTACCCGCGAGGTCGTACGTCCGCACCT
CACGAACGTCACCGTCGCCCCGATCACGACAACCGTGCGTGGGCTAGCCACCGAAGTCCCGGTAGACGCGGTGAACGGGC
TGAATCAACCGTCAGTCGTCAGCTGCGACAACACCCAAACGATCCCGGTGTGTGACCTTGGTCGTCAAATCGGCTACCTG
CTCGCGTCGCAGGAGCCGGCTCTAGCCGAGGCCATCGGCAACGCGTTCGACCTCGATTGGGTGGTGGCATAG

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11394.83 Da        Isoelectric Point: 5.1236

>AT83384 WP_003405836.1 NZ_CP023601:c1231190-1230870 [Mycobacterium tuberculosis]
MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEI
LATNTSATGDLDTLAGHCARTALDID

Download         Length: 321 bp

>AT83384 NZ_CP023601:c1231190-1230870 [Mycobacterium tuberculosis]
ATGTACCTACCCTGGGGGGTCGTCCTCGCCGGCGGCGCGAACGGTTTTGGGGCGGGTGCATACCAAACTGGTACCATCTG
TGAAGTGAGTACACAGATTGCGGTTCGCTTGCCCGATGAGATTGTCGCGTTCATCGACGACGAAGTCCGGGGACAGCATG
CCCGTAGCCGTGCGGCTGTCGTGCTGCGGGCGCTGGAACGGGAACGCCGCCGTCGTCTCGCCGAACGCGACGCGGAGATC
CTCGCCACCAACACGTCAGCCACGGGTGATCTGGATACGCTGGCCGGCCACTGCGCTCGTACCGCCCTCGACATCGACTG
A

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB5CCA
PDB5UCT

Antitoxin

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Source
ID
Structure
AlphaFold DBG0TGZ7

References