Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 703196..703839 Replicon chromosome
Accession NZ_CP023601
Organism Mycobacterium tuberculosis strain CSV9577

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag CP457_RS03255 Protein ID WP_003403187.1
Coordinates 703438..703839 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag CP457_RS03250 Protein ID WP_003403184.1
Coordinates 703196..703441 (+) Length 82 a.a.

Genomic Context

CP457_RS03225CP457_RS03230CP457_RS03235CP457_RS03240CP457_RS03245CP457_RS03250CP457_RS03255CP457_RS03285CP457_RS03215CP457_RS03220CP457_RS21475CP457_RS21480CP457_RS03275CP457_RS03280
Location: 699808..700119 (312 bp)
Type: Others
Protein ID: WP_003403164.1
Location: 700191..701141 (951 bp)
Type: Others
Protein ID: WP_003900184.1
Location: 701382..701966 (585 bp)
Type: Others
Protein ID: WP_003403171.1
Location: 701968..702678 (711 bp)
Type: Others
Protein ID: Protein_626
Location: 702681..703151 (471 bp)
Type: Others
Protein ID: WP_003898523.1
Location: 703196..703441 (246 bp)
Type: Antitoxin
Protein ID: WP_003403184.1
Location: 703438..703839 (402 bp)
Type: Toxin
Protein ID: WP_003403187.1
Location: 706276..706881 (606 bp)
Type: Others
Protein ID: WP_003898526.1
Location: 698476..699006 (531 bp)
Type: Others
Protein ID: WP_003917320.1
Location: 698990..699685 (696 bp)
Type: Others
Protein ID: WP_003918099.1
Location: 704227..704394 (168 bp)
Type: Others
Protein ID: WP_077385191.1
Location: 704427..704624 (198 bp)
Type: Others
Protein ID: WP_003403191.1
Location: 704704..705861 (1158 bp)
Type: Others
Protein ID: WP_003898524.1
Location: 705913..706134 (222 bp)
Type: Others
Protein ID: WP_003898525.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CP457_RS03215698476..699006-531WP_003917320.1two component system sensor kinase HK2-
CP457_RS03220698990..699685-696WP_003918099.1two-component system response regulator TcrA-
CP457_RS03225699808..700119+312WP_003403164.1hypothetical protein-
CP457_RS03230700191..701141+951WP_003900184.1DUF1259 domain-containing protein-
CP457_RS03235701382..701966+585WP_003403171.1IS607-like element IS1536 family transposase-
CP457_RS03240701968..702678+711Protein_626transposase-
CP457_RS03245702681..703151+471WP_003898523.1hypothetical protein-
CP457_RS03250703196..703441+246WP_003403184.1type II toxin-antitoxin system VapB family antitoxinAntitoxin
CP457_RS03255703438..703839+402WP_003403187.1type II toxin-antitoxin system VapC family toxinToxin
CP457_RS21475704227..704394-168WP_077385191.1DUF3800 domain-containing protein-
CP457_RS21480704427..704624-198WP_003403191.1hypothetical protein-
CP457_RS03275704704..705861-1158WP_003898524.1hypothetical protein-
CP457_RS03280705913..706134-222WP_003898525.1DUF4926 domain-containing protein-
CP457_RS03285706276..706881+606WP_003898526.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T83372 WP_003403187.1 NZ_CP023601:703438-703839 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T83372 NZ_CP023601:703438-703839 [Mycobacterium tuberculosis]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT83372 WP_003403184.1 NZ_CP023601:703196-703441 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT83372 NZ_CP023601:703196-703441 [Mycobacterium tuberculosis]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A7U4BSD6

Antitoxin

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Source
ID
Structure
AlphaFold DBG0TQ91

References