Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Rv0299-vapB/-
Location 363463..364034 Replicon chromosome
Accession NZ_CP023601
Organism Mycobacterium tuberculosis strain CSV9577

Toxin (Protein)


Gene name Rv0299 Uniprot ID -
Locus tag CP457_RS01610 Protein ID WP_003401560.1
Coordinates 363463..363765 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag CP457_RS01615 Protein ID WP_003401563.1
Coordinates 363813..364034 (+) Length 74 a.a.

Genomic Context

CP457_RS01600CP457_RS01605CP457_RS01610CP457_RS01615CP457_RS01620CP457_RS01625CP457_RS01630CP457_RS01590CP457_RS01595
Location: 361321..363096 (1776 bp)
Type: Others
Protein ID: WP_010886074.1
Location: 363239..363466 (228 bp)
Type: Others
Protein ID: WP_003401555.1
Location: 363463..363765 (303 bp)
Type: Toxin
Protein ID: WP_003401560.1
Location: 363813..364034 (222 bp)
Type: Antitoxin
Protein ID: WP_003401563.1
Location: 364031..364456 (426 bp)
Type: Others
Protein ID: WP_003401566.1
Location: 364592..365224 (633 bp)
Type: Others
Protein ID: WP_003401571.1
Location: 365221..366129 (909 bp)
Type: Others
Protein ID: WP_003900117.1
Location: 358932..359735 (804 bp)
Type: Others
Protein ID: WP_003401540.1
Location: 359745..361142 (1398 bp)
Type: Others
Protein ID: WP_003401544.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CP457_RS01590358932..359735-804WP_003401540.1hypothetical protein-
CP457_RS01595359745..361142-1398WP_003401544.1sulfatase-
CP457_RS01600361321..363096+1776WP_010886074.1PE family protein-
CP457_RS01605363239..363466+228WP_003401555.1ribbon-helix-helix protein, CopG family-
CP457_RS01610363463..363765+303WP_003401560.1toxin-antitoxin system toxinToxin
CP457_RS01615363813..364034+222WP_003401563.1type II toxin-antitoxin system antitoxin VapB2Antitoxin
CP457_RS01620364031..364456+426WP_003401566.1PIN domain nuclease-
CP457_RS01625364592..365224+633WP_003401571.1TetR/AcrR family transcriptional regulator-
CP457_RS01630365221..366129+909WP_003900117.1SDR family NAD(P)-dependent oxidoreductase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 10442.16 Da        Isoelectric Point: 4.9609

>T83365 WP_003401560.1 NZ_CP023601:363463-363765 [Mycobacterium tuberculosis]
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Download         Length: 303 bp

>T83365 NZ_CP023601:363463-363765 [Mycobacterium tuberculosis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT83365 WP_003401563.1 NZ_CP023601:363813-364034 [Mycobacterium tuberculosis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp

>AT83365 NZ_CP023601:363813-364034 [Mycobacterium tuberculosis]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
PDB3H87
AlphaFold DBA0A829CG48

References