Detailed information of TA system TA083281

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2363842..2364537
• Replicon: chromosome
• Accession: NZ_CP023599
• Organism: Mycobacterium tuberculosis strain CSV383

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CP455_RS11455
• Protein ID: WP_003905754.1
• Coordinates: 2363842..2364276 (-)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TMN0
• Locus tag: CP455_RS11460
• Protein ID: WP_003410814.1
• Coordinates: 2364283..2364537 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CP455_RS11445	2359996..2363037	+	3042	WP_003899171.1	DEAD/DEAH box helicase	-
CP455_RS11450	2363030..2363863	+	834	WP_003899172.1	SWIM zinc finger family protein	-
CP455_RS11455	2363842..2364276	-	435	WP_003905754.1	type II toxin-antitoxin system VapC family toxin	Toxin
CP455_RS11460	2364283..2364537	-	255	WP_003410814.1	antitoxin	Antitoxin
CP455_RS11465	2364553..2364810	-	258	WP_003410816.1	hypothetical protein	-
CP455_RS11475	2365221..2366482	+	1262	WP_087902221.1	IS3-like element IS987 family transposase	-
CP455_RS11480	2367115..2367411	+	297	WP_003410820.1	PE family protein	-
CP455_RS11485	2367467..2368198	+	732	WP_003900467.1	PPE family protein	-
CP455_RS11490	2368738..2369484	-	747	WP_003901330.1	proteasome subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (1-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 15632.05 Da
• Isoelectric Point: 7.4681

>T83281 WP_003905754.1 NZ_CP023599:c2364276-2363842 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTASEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Nucleotide

• Length: 435 bp

>T83281 NZ_CP023599:c2364276-2363842 [Mycobacterium tuberculosis]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCGCAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9417.57 Da
• Isoelectric Point: 8.9912

>AT83281 WP_003410814.1 NZ_CP023599:c2364537-2364283 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Nucleotide

• Length: 255 bp

>AT83281 NZ_CP023599:c2364537-2364283 [Mycobacterium tuberculosis]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Structures

Antitoxin

• AlphaFold DB: G0TMN0