83262

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1230512..1231059 Replicon chromosome
Accession NZ_CP023599
Organism Mycobacterium tuberculosis strain CSV383

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U4F9D0
Locus tag CP455_RS06055 Protein ID WP_003405820.1
Coordinates 1230512..1230823 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q8VK70
Locus tag CP455_RS06060 Protein ID WP_003913656.1
Coordinates 1230823..1231059 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP455_RS06035 1225993..1227417 - 1425 WP_003405805.1 class II fumarate hydratase -
CP455_RS06040 1227448..1228536 - 1089 WP_003898726.1 class II fructose-bisphosphatase -
CP455_RS06045 1228592..1229236 + 645 WP_003915494.1 DUF4245 domain-containing protein -
CP455_RS06050 1229243..1230400 - 1158 WP_003898727.1 AI-2E family transporter -
CP455_RS06055 1230512..1230823 - 312 WP_003405820.1 type II toxin-antitoxin system toxin endoribonuclease MazF3 Toxin
CP455_RS06060 1230823..1231059 - 237 WP_003913656.1 hypothetical protein Antitoxin
CP455_RS06065 1231152..1232677 + 1526 Protein_1145 carboxylesterase/lipase family protein -
CP455_RS06070 1232695..1233807 - 1113 WP_003405840.1 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase -
CP455_RS06075 1233817..1234074 - 258 WP_003405844.1 exodeoxyribonuclease VII small subunit -
CP455_RS06080 1234064..1235311 - 1248 WP_003405846.1 exodeoxyribonuclease VII large subunit -
CP455_RS06085 1235308..1235946 - 639 WP_003898730.1 lipid droplet-associated protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11061.82 Da        Isoelectric Point: 4.9371

>T83262 WP_003405820.1 NZ_CP023599:c1230823-1230512 [Mycobacterium tuberculosis]
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNIQTIPVCDLGRQIGYL
LASQEPALAEAIGNAFDLDWVVA

Download         Length: 312 bp

>T83262 NZ_CP023599:c1230823-1230512 [Mycobacterium tuberculosis]
ATGCGACCTATCCACATCGCACAGCTTGACAAGGCTAGACCCGTCCTGATCCTTACCCGCGAGGTCGTACGTCCGCACCT
CACGAACGTCACCGTCGCCCCGATCACGACAACCGTGCGTGGGCTAGCCACCGAAGTCCCGGTAGACGCGGTGAACGGGC
TGAATCAACCGTCAGTCGTCAGCTGCGACAACATCCAAACGATCCCGGTGTGTGACCTTGGTCGTCAAATCGGCTACCTG
CTCGCGTCGCAGGAGCCGGCTCTAGCCGAGGCCATCGGCAACGCGTTCGACCTCGATTGGGTGGTGGCATAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8608.66 Da        Isoelectric Point: 5.6908

>AT83262 WP_003913656.1 NZ_CP023599:c1231059-1230823 [Mycobacterium tuberculosis]
VSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEILATNTSATGDLDTLAGHCARTALDID

Download         Length: 237 bp

>AT83262 NZ_CP023599:c1231059-1230823 [Mycobacterium tuberculosis]
GTGAGTACACAGATTGCGGTTCGCTTGCCCGATGAGATTGTCGCGTTCATCGACGACGAAGTCCGGGGACAGCATGCCCG
TAGCCGTGCGGCTGTCGTGCTGCGGGCGCTGGAACGGGAACGCCGCCGTCGTCTCGCCGAACGCGACGCGGAGATCCTCG
CCACCAACACGTCAGCCACGGGTGATCTGGATACGCTGGCCGGCCACTGCGCTCGTACCGCCCTCGACATCGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F9D0

Antitoxin

Source ID Structure
AlphaFold DB Q8VK70

References