Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3707325..3707999 Replicon chromosome
Accession NZ_CP023595
Organism Mycobacterium tuberculosis strain SLM060

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag CP451_RS18165 Protein ID WP_003417282.1
Coordinates 3707325..3707753 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag CP451_RS18170 Protein ID WP_003417286.1
Coordinates 3707757..3707999 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP451_RS18140 3703147..3703548 - 402 WP_003417264.1 cytidine deaminase -
CP451_RS18145 3703689..3704123 + 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
CP451_RS18150 3704120..3704554 + 435 WP_003902441.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
CP451_RS18155 3704683..3706455 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
CP451_RS18160 3706455..3707246 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
CP451_RS18165 3707325..3707753 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
CP451_RS18170 3707757..3707999 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
CP451_RS18175 3708121..3708735 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
CP451_RS18180 3708732..3709397 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
CP451_RS18185 3709398..3709931 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
CP451_RS21895 3709928..3710080 - 153 WP_003916129.1 hypothetical protein -
CP451_RS18195 3710116..3711377 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T83055 WP_003417282.1 NZ_CP023595:c3707753-3707325 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T83055 NZ_CP023595:c3707753-3707325 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT83055 WP_003417286.1 NZ_CP023595:c3707999-3707757 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT83055 NZ_CP023595:c3707999-3707757 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References