Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 710690..711315 Replicon chromosome
Accession NZ_CP023595
Organism Mycobacterium tuberculosis strain SLM060

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag CP451_RS03310 Protein ID WP_003403218.1
Coordinates 710914..711315 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag CP451_RS03305 Protein ID WP_003403213.1
Coordinates 710690..710917 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP451_RS03275 705869..706090 - 222 WP_003898525.1 DUF4926 domain-containing protein -
CP451_RS03280 706232..706837 + 606 WP_003898526.1 hypothetical protein -
CP451_RS03285 706856..709423 - 2568 WP_003901879.1 SEC-C domain-containing protein -
CP451_RS03290 709507..710256 + 750 WP_003898528.1 hypothetical protein -
CP451_RS03295 710253..710495 + 243 WP_003403210.1 hypothetical protein -
CP451_RS03305 710690..710917 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
CP451_RS03310 710914..711315 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
CP451_RS03315 711444..712139 + 696 WP_003900189.1 galactose-1-phosphate uridylyltransferase -
CP451_RS03320 712136..712627 + 492 WP_003905354.1 galactose-1-phosphate uridylyltransferase -
CP451_RS03325 712624..713715 + 1092 WP_003900977.1 galactokinase -
CP451_RS03335 714110..715174 + 1065 WP_003898532.1 hypothetical protein -
CP451_RS03340 715278..716225 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T83009 WP_003403218.1 NZ_CP023595:710914-711315 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T83009 NZ_CP023595:710914-711315 [Mycobacterium tuberculosis]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT83009 WP_003403213.1 NZ_CP023595:710690-710917 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT83009 NZ_CP023595:710690-710917 [Mycobacterium tuberculosis]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References