83007

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/AbrB(antitoxin)
Location 697062..697708 Replicon chromosome
Accession NZ_CP023595
Organism Mycobacterium tuberculosis strain SLM060

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ88
Locus tag CP451_RS03195 Protein ID WP_003403137.1
Coordinates 697062..697475 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ89
Locus tag CP451_RS03200 Protein ID WP_003403139.1
Coordinates 697472..697708 (-) Length 79 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP451_RS03175 693145..694695 + 1551 WP_003905349.1 MCE family protein -
CP451_RS03180 694747..695139 - 393 WP_003403122.1 type II toxin-antitoxin system toxin ribonuclease C4 -
CP451_RS03185 695136..695393 - 258 WP_003403125.1 type II toxin-antitoxin system antitoxin VapB4 -
CP451_RS03190 695576..696811 - 1236 WP_003403128.1 ATP-binding protein -
CP451_RS03195 697062..697475 - 414 WP_003403137.1 type II toxin-antitoxin system VapC family toxin Toxin
CP451_RS03200 697472..697708 - 237 WP_003403139.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CP451_RS03205 697812..698318 - 507 WP_003900973.1 two component system sensor kinase HK1 -
CP451_RS03210 698432..698962 - 531 WP_003917320.1 two component system sensor kinase HK2 -
CP451_RS03215 698946..699641 - 696 WP_003918099.1 two-component system response regulator TcrA -
CP451_RS03220 699764..700075 + 312 WP_003403164.1 hypothetical protein -
CP451_RS03225 700147..701097 + 951 WP_003900184.1 DUF1259 domain-containing protein -
CP451_RS03230 701338..701922 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
CP451_RS03235 701924..702634 + 711 Protein_626 transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(7-126)

Antitoxin

(3-43)


Sequences


Toxin        


Download         Length: 138 a.a.        Molecular weight: 14786.14 Da        Isoelectric Point: 8.1405

>T83007 WP_003403137.1 NZ_CP023595:c697475-697062 [Mycobacterium tuberculosis]
VKPPLAVDTSVAIPLLVRTHTAHAAVVAWWAHREAALCGHALAETYSVLTRLPRDLRLAPMDAARLLTERFAAPLLLSSR
TTEHLPRVLAQFEITGGAVYDALVALAAAEHRAELATRDARAKDTYEKIGVHVVVAA

Download         Length: 414 bp

>T83007 NZ_CP023595:c697475-697062 [Mycobacterium tuberculosis]
GTGAAACCGCCGCTGGCAGTGGACACCAGCGTCGCGATTCCGTTGCTGGTACGGACCCATACCGCGCATGCGGCGGTTGT
CGCCTGGTGGGCACATCGGGAGGCCGCGCTGTGCGGGCACGCCCTGGCCGAAACCTACTCCGTGCTGACCCGCCTGCCGC
GTGACCTACGACTGGCACCGATGGACGCCGCGCGGCTTCTTACCGAACGCTTTGCGGCACCGCTGTTGTTGAGTTCCCGC
ACCACTGAACATCTCCCACGCGTGCTGGCCCAATTCGAGATCACTGGTGGCGCGGTCTATGACGCTCTCGTGGCCCTTGC
CGCCGCCGAGCACCGGGCTGAACTCGCCACACGCGATGCTCGAGCCAAGGACACTTACGAAAAGATCGGCGTCCACGTCG
TTGTCGCCGCGTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8212.41 Da        Isoelectric Point: 5.0351

>AT83007 WP_003403139.1 NZ_CP023595:c697708-697472 [Mycobacterium tuberculosis]
MKAVVDAAGRIVVPKPLREALGLQPGSTVEISRYGAGLHLIPTGRTARLEEENGVLVATGETTIDDEVVFGLIDSGRK

Download         Length: 237 bp

>AT83007 NZ_CP023595:c697708-697472 [Mycobacterium tuberculosis]
ATGAAGGCTGTTGTGGATGCGGCTGGCCGCATCGTCGTACCCAAACCGCTGCGCGAAGCCTTGGGGCTGCAACCGGGGTC
CACCGTGGAAATATCCCGCTATGGCGCTGGTCTCCACCTGATTCCCACCGGACGAACAGCGCGTCTCGAAGAGGAGAATG
GCGTACTGGTGGCCACCGGTGAGACCACGATCGACGATGAGGTCGTGTTCGGCCTTATCGATAGCGGCCGGAAGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TQ88


Antitoxin

Source ID Structure
AlphaFold DB G0TQ89

References