Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2203627..2204171 Replicon chromosome
Accession NZ_CP023593
Organism Mycobacterium tuberculosis strain SLM040

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag CP449_RS10645 Protein ID WP_003409896.1
Coordinates 2203627..2203923 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag CP449_RS10650 Protein ID WP_003409899.1
Coordinates 2203920..2204171 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP449_RS10590 2198660..2199010 - 351 WP_003899096.1 hypothetical protein -
CP449_RS10595 2199021..2199923 - 903 WP_003899097.1 hypothetical protein -
CP449_RS10600 2199944..2200135 - 192 WP_003409876.1 hypothetical protein -
CP449_RS10605 2200136..2200432 - 297 WP_003409877.1 hypothetical protein -
CP449_RS10610 2200672..2200887 + 216 WP_003409878.1 antitoxin -
CP449_RS10615 2200884..2201195 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
CP449_RS21810 2201169..2201690 - 522 WP_164919314.1 hypothetical protein -
CP449_RS10625 2201665..2202042 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
CP449_RS10630 2202084..2202533 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
CP449_RS10635 2202530..2203075 + 546 WP_003899098.1 SecB-like chaperone -
CP449_RS10640 2202964..2203578 - 615 WP_003901296.1 hypothetical protein -
CP449_RS10645 2203627..2203923 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CP449_RS10650 2203920..2204171 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
CP449_RS10655 2204158..2204652 + 495 WP_003899099.1 hypothetical protein -
CP449_RS10660 2204812..2205219 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
CP449_RS10665 2205223..2205495 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
CP449_RS10670 2205528..2206748 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
CP449_RS10685 2207647..2208444 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T82910 WP_003409896.1 NZ_CP023593:c2203923-2203627 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T82910 NZ_CP023593:c2203923-2203627 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT82910 WP_003409899.1 NZ_CP023593:c2204171-2203920 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT82910 NZ_CP023593:c2204171-2203920 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References