Detailed information of TA system TA082796

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2363989..2364684
• Replicon: chromosome
• Accession: NZ_CP023591
• Organism: Mycobacterium tuberculosis strain TBV5365

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CP447_RS11425
• Protein ID: WP_096872183.1
• Coordinates: 2363989..2364423 (-)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TMN0
• Locus tag: CP447_RS11430
• Protein ID: WP_003410814.1
• Coordinates: 2364430..2364684 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CP447_RS11415	2360143..2363184	+	3042	WP_003899171.1	DEAD/DEAH box helicase	-
CP447_RS11420	2363177..2364010	+	834	WP_003899172.1	SWIM zinc finger family protein	-
CP447_RS11425	2363989..2364423	-	435	WP_096872183.1	type II toxin-antitoxin system VapC family toxin	Toxin
CP447_RS11430	2364430..2364684	-	255	WP_003410814.1	antitoxin	Antitoxin
CP447_RS11435	2364700..2364957	-	258	WP_003410816.1	hypothetical protein	-
CP447_RS11445	2365369..2366630	+	1262	WP_087902221.1	IS3-like element IS987 family transposase	-
CP447_RS11450	2367263..2367559	+	297	WP_003410820.1	PE family protein	-
CP447_RS11455	2367615..2368346	+	732	WP_003900467.1	PPE family protein	-
CP447_RS11460	2368886..2369632	-	747	WP_096872185.1	proteasome subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (1-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 15662.08 Da
• Isoelectric Point: 7.4681

>T82796 WP_096872183.1 NZ_CP023591:c2364423-2363989 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Nucleotide

• Length: 435 bp

>T82796 NZ_CP023591:c2364423-2363989 [Mycobacterium tuberculosis]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9417.57 Da
• Isoelectric Point: 8.9912

>AT82796 WP_003410814.1 NZ_CP023591:c2364684-2364430 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Nucleotide

• Length: 255 bp

>AT82796 NZ_CP023591:c2364684-2364430 [Mycobacterium tuberculosis]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Structures

Antitoxin

• AlphaFold DB: G0TMN0