Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC(toxin) |
Location | 1967658..1968118 | Replicon | chromosome |
Accession | NZ_CP023591 | ||
Organism | Mycobacterium tuberculosis strain TBV5365 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | G0TKL9 |
Locus tag | CP447_RS09485 | Protein ID | WP_003898996.1 |
Coordinates | 1967870..1968118 (+) | Length | 83 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | P9WJ30 |
Locus tag | CP447_RS09480 | Protein ID | WP_003408528.1 |
Coordinates | 1967658..1967870 (+) | Length | 71 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CP447_RS09465 | 1964136..1965323 | - | 1188 | WP_003898992.1 | nitrate transporter NarK | - |
CP447_RS09470 | 1965610..1965894 | + | 285 | WP_003408522.1 | DUF1876 domain-containing protein | - |
CP447_RS09475 | 1965908..1967590 | - | 1683 | WP_003898994.1 | SulP family inorganic anion transporter | - |
CP447_RS09480 | 1967658..1967870 | + | 213 | WP_003408528.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
CP447_RS09485 | 1967870..1968118 | + | 249 | WP_003898996.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
CP447_RS09490 | 1968126..1968863 | + | 738 | WP_003898997.1 | hypothetical protein | - |
CP447_RS09495 | 1968957..1970657 | + | 1701 | WP_003898998.1 | serine/threonine protein kinase PknE | - |
CP447_RS09500 | 1970942..1971343 | - | 402 | WP_003408538.1 | hypothetical protein | - |
CP447_RS09505 | 1971333..1971944 | - | 612 | WP_003898999.1 | isopentenyl-diphosphate Delta-isomerase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 83 a.a. Molecular weight: 8884.14 Da Isoelectric Point: 4.1074
>T82786 WP_003898996.1 NZ_CP023591:1967870-1968118 [Mycobacterium tuberculosis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG
Download Length: 249 bp
>T82786 NZ_CP023591:1967870-1968118 [Mycobacterium tuberculosis]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA
Antitoxin
Download Length: 71 a.a. Molecular weight: 7607.80 Da Isoelectric Point: 9.3146
>AT82786 WP_003408528.1 NZ_CP023591:1967658-1967870 [Mycobacterium tuberculosis]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA
Download Length: 213 bp
>AT82786 NZ_CP023591:1967658-1967870 [Mycobacterium tuberculosis]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TKL9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829CFE8 |