Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 1388623..1389182 Replicon chromosome
Accession NZ_CP023591
Organism Mycobacterium tuberculosis strain TBV5365

Toxin (Protein)


Gene name relE Uniprot ID G0THS1
Locus tag CP447_RS06810 Protein ID WP_003898789.1
Coordinates 1388623..1388916 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0THS2
Locus tag CP447_RS06815 Protein ID WP_003406322.1
Coordinates 1388913..1389182 (-) Length 90 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP447_RS06780 1384216..1384476 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 -
CP447_RS06785 1384473..1384904 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin -
CP447_RS06790 1384927..1386615 - 1689 WP_003910308.1 PE family protein -
CP447_RS06800 1386795..1387655 + 861 WP_003900301.1 hypothetical protein -
CP447_RS06805 1387736..1388566 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
CP447_RS06810 1388623..1388916 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
CP447_RS06815 1388913..1389182 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CP447_RS06820 1389295..1392990 - 3696 WP_096865453.1 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit -
CP447_RS06825 1393132..1393920 - 789 WP_096872019.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 98 a.a.        Molecular weight: 11031.57 Da        Isoelectric Point: 9.6275

>T82780 WP_003898789.1 NZ_CP023591:c1388916-1388623 [Mycobacterium tuberculosis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Download         Length: 294 bp

>T82780 NZ_CP023591:c1388916-1388623 [Mycobacterium tuberculosis]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9766.97 Da        Isoelectric Point: 4.8615

>AT82780 WP_003406322.1 NZ_CP023591:c1389182-1388913 [Mycobacterium tuberculosis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Download         Length: 270 bp

>AT82780 NZ_CP023591:c1389182-1388913 [Mycobacterium tuberculosis]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0THS1


Antitoxin

Source ID Structure
AlphaFold DB G0THS2

References