Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1239351..1239919 Replicon chromosome
Accession NZ_CP023591
Organism Mycobacterium tuberculosis strain TBV5365

Toxin (Protein)


Gene name vapC Uniprot ID G0TH08
Locus tag CP447_RS06090 Protein ID WP_003405865.1
Coordinates 1239545..1239919 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TH07
Locus tag CP447_RS06085 Protein ID WP_003405863.1
Coordinates 1239351..1239548 (+) Length 66 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP447_RS06065 1235392..1236030 - 639 WP_003898730.1 lipid droplet-associated protein -
CP447_RS06070 1236120..1237127 + 1008 WP_003405853.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
CP447_RS06075 1237144..1238127 - 984 WP_003898731.1 hypothetical protein -
CP447_RS06080 1238190..1239263 + 1074 WP_003898732.1 redox-regulated ATPase YchF -
CP447_RS06085 1239351..1239548 + 198 WP_003405863.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
CP447_RS06090 1239545..1239919 + 375 WP_003405865.1 type II toxin-antitoxin system VapC family toxin Toxin
CP447_RS06095 1240122..1240820 + 699 WP_003898733.1 hypothetical protein -
CP447_RS06100 1240938..1241123 + 186 WP_003901093.1 hypothetical protein -
CP447_RS06105 1241050..1241325 - 276 WP_003405867.1 hypothetical protein -
CP447_RS06110 1241568..1241891 + 324 WP_003405871.1 antibiotic biosynthesis monooxygenase -
CP447_RS06115 1241906..1242616 - 711 WP_003911399.1 hypothetical protein -
CP447_RS21735 1242638..1242847 + 210 WP_003911400.1 hypothetical protein -
CP447_RS06120 1242799..1243506 - 708 Protein_1162 adenylate/guanylate cyclase domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-111)

Antitoxin

(1-42)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 13444.56 Da        Isoelectric Point: 5.1881

>T82778 WP_003405865.1 NZ_CP023591:1239545-1239919 [Mycobacterium tuberculosis]
VILVDTSVWIEHLRAADARLVELLGDDEAGCHPLVIEELALGSIKQRDVVLDLLANLYQFPVVTHDEVLRLVGRRRLWGR
GLGAVDANLLGSVALVGGARLWTRDKRLKAACAESGVALAEEVS

Download         Length: 375 bp

>T82778 NZ_CP023591:1239545-1239919 [Mycobacterium tuberculosis]
GTGATCCTGGTCGACACTTCGGTATGGATTGAGCACCTGCGCGCCGCCGACGCGCGACTCGTCGAGCTGCTGGGCGATGA
CGAGGCCGGTTGCCATCCGCTCGTCATCGAGGAGCTGGCGCTTGGCTCGATCAAGCAGCGAGACGTTGTTCTCGATCTGT
TGGCCAACCTCTACCAGTTTCCGGTGGTGACCCACGACGAAGTGTTGCGGCTTGTCGGTCGGCGGCGGTTGTGGGGTCGG
GGACTCGGTGCCGTCGATGCCAACCTTCTTGGTTCGGTGGCTCTGGTTGGCGGCGCGCGACTATGGACGCGGGACAAGCG
GTTGAAGGCGGCGTGCGCGGAAAGCGGTGTTGCGCTGGCTGAGGAAGTGTCCTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 6973.03 Da        Isoelectric Point: 11.7327

>AT82778 WP_003405863.1 NZ_CP023591:1239351-1239548 [Mycobacterium tuberculosis]
MRTTVTVDDALLAKAAELTGVKEKSTLLREGLQTLVRVESARRLAALGGTDPQATAAPRRRTSPR

Download         Length: 198 bp

>AT82778 NZ_CP023591:1239351-1239548 [Mycobacterium tuberculosis]
ATGAGGACGACGGTGACCGTTGACGACGCCTTGTTAGCCAAAGCGGCCGAATTGACTGGGGTGAAAGAGAAGTCGACGCT
CCTGCGCGAGGGGTTGCAGACACTGGTCCGGGTGGAGAGCGCCCGGCGGTTGGCGGCTCTCGGCGGCACCGACCCGCAAG
CTACCGCGGCGCCGAGACGCCGGACGTCGCCCCGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TH08


Antitoxin

Source ID Structure
AlphaFold DB G0TH07

References