Detailed information of TA system TA082736

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/-
• Location: 2402011..2402540
• Replicon: chromosome
• Accession: NZ_CP023590
• Organism: Mycobacterium tuberculosis strain TBV5362

Toxin (Protein)

• Gene name: parE
• Uniprot ID: G0TMR4
• Locus tag: CP446_RS11645
• Protein ID: WP_003411124.1
• Coordinates: 2402011..2402328 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: P9WJ74
• Locus tag: CP446_RS11650
• Protein ID: WP_003411127.1
• Coordinates: 2402325..2402540 (-)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CP446_RS11615	2397205..2398281	+	1077	WP_003411110.1	hypothetical protein	-
CP446_RS11620	2398278..2398559	+	282	WP_003411112.1	hypothetical protein	-
CP446_RS11625	2398595..2399668	+	1074	WP_003411116.1	quinone-dependent dihydroorotate dehydrogenase	-
CP446_RS11630	2399673..2400203	-	531	WP_003411119.1	YbhB/YbcL family Raf kinase inhibitor-like protein	-
CP446_RS11635	2400251..2401597	-	1347	WP_003411121.1	M20/M25/M40 family metallo-hydrolase	-
CP446_RS11645	2402011..2402328	-	318	WP_003411124.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CP446_RS11650	2402325..2402540	-	216	WP_003411127.1	antitoxin ParD2	Antitoxin
CP446_RS11655	2402795..2403853	+	1059	WP_003411129.1	hypothetical protein	-
CP446_RS11660	2403983..2404339	-	357	WP_003411130.1	hypothetical protein	-
CP446_RS11665	2404434..2405216	-	783	WP_003411131.1	cell wall synthesis protein Wag31	-
CP446_RS11670	2405484..2405774	-	291	WP_003900476.1	YggT family protein	-
CP446_RS11675	2405936..2406592	-	657	WP_003411133.1	cell division protein SepF	-
CP446_RS11680	2406658..2407434	-	777	WP_003411137.1	YggS family pyridoxal phosphate-dependent enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-92)

Antitoxin

• Conserved hypothetical protein CHP02574, addiction module (11-69)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12312.88 Da
• Isoelectric Point: 6.4831

>T82736 WP_003411124.1 NZ_CP023590:c2402328-2402011 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Nucleotide

• Length: 318 bp

>T82736 NZ_CP023590:c2402328-2402011 [Mycobacterium tuberculosis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 7880.70 Da
• Isoelectric Point: 4.4055

>AT82736 WP_003411127.1 NZ_CP023590:c2402540-2402325 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Nucleotide

• Length: 216 bp

>AT82736 NZ_CP023590:c2402540-2402325 [Mycobacterium tuberculosis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Structures

Toxin

• AlphaFold DB: G0TMR4

Antitoxin

• AlphaFold DB: A0A7U4FAJ4