Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2203562..2204106 | Replicon | chromosome |
| Accession | NZ_CP023590 | ||
| Organism | Mycobacterium tuberculosis strain TBV5362 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | CP446_RS10645 | Protein ID | WP_003409896.1 |
| Coordinates | 2203562..2203858 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | CP446_RS10650 | Protein ID | WP_003409899.1 |
| Coordinates | 2203855..2204106 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CP446_RS10590 | 2198595..2198945 | - | 351 | WP_003899096.1 | hypothetical protein | - |
| CP446_RS10595 | 2198956..2199858 | - | 903 | WP_003899097.1 | hypothetical protein | - |
| CP446_RS10600 | 2199879..2200070 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| CP446_RS10605 | 2200071..2200367 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| CP446_RS10610 | 2200607..2200822 | + | 216 | WP_003409878.1 | antitoxin | - |
| CP446_RS10615 | 2200819..2201130 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| CP446_RS21840 | 2201104..2201625 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| CP446_RS10625 | 2201600..2201977 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| CP446_RS10630 | 2202019..2202468 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| CP446_RS10635 | 2202465..2203010 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| CP446_RS10640 | 2202899..2203513 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| CP446_RS10645 | 2203562..2203858 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| CP446_RS10650 | 2203855..2204106 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| CP446_RS10655 | 2204093..2204587 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| CP446_RS10660 | 2204747..2205154 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| CP446_RS10665 | 2205158..2205430 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| CP446_RS10670 | 2205463..2206683 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| CP446_RS10685 | 2207582..2208379 | + | 798 | WP_003899101.1 | ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T82728 WP_003409896.1 NZ_CP023590:c2203858-2203562 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T82728 NZ_CP023590:c2203858-2203562 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT82728 WP_003409899.1 NZ_CP023590:c2204106-2203855 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT82728 NZ_CP023590:c2204106-2203855 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |