Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 710658..711283 Replicon chromosome
Accession NZ_CP023590
Organism Mycobacterium tuberculosis strain TBV5362

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag CP446_RS03305 Protein ID WP_003403218.1
Coordinates 710882..711283 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag CP446_RS03300 Protein ID WP_003403213.1
Coordinates 710658..710885 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP446_RS03270 705837..706058 - 222 WP_003898525.1 DUF4926 domain-containing protein -
CP446_RS03275 706200..706805 + 606 WP_003898526.1 hypothetical protein -
CP446_RS03280 706824..709391 - 2568 WP_009937370.1 SEC-C domain-containing protein -
CP446_RS03285 709475..710224 + 750 WP_003898528.1 hypothetical protein -
CP446_RS03290 710221..710463 + 243 WP_003403210.1 hypothetical protein -
CP446_RS03300 710658..710885 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
CP446_RS03305 710882..711283 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
CP446_RS21700 711412..712107 + 696 WP_003900189.1 galactose-1-phosphate uridylyltransferase -
CP446_RS21705 712104..712595 + 492 WP_012054156.1 galactose-1-phosphate uridylyltransferase -
CP446_RS03320 712592..713683 + 1092 WP_003906403.1 galactokinase -
CP446_RS03330 714078..715142 + 1065 WP_003898532.1 hypothetical protein -
CP446_RS03335 715246..716193 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T82705 WP_003403218.1 NZ_CP023590:710882-711283 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T82705 NZ_CP023590:710882-711283 [Mycobacterium tuberculosis]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT82705 WP_003403213.1 NZ_CP023590:710658-710885 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT82705 NZ_CP023590:710658-710885 [Mycobacterium tuberculosis]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References