Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2869469..2870106 Replicon chromosome
Accession NZ_CP023587
Organism Mycobacterium tuberculosis strain ME1473

Toxin (Protein)


Gene name vapC Uniprot ID P0DMV7
Locus tag CP443_RS13975 Protein ID WP_003413180.1
Coordinates 2869469..2869864 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ44
Locus tag CP443_RS13980 Protein ID WP_003413183.1
Coordinates 2869861..2870106 (-) Length 82 a.a.

Genomic Context

CP443_RS13930CP443_RS13940CP443_RS13945CP443_RS13950CP443_RS13955CP443_RS13960CP443_RS13965CP443_RS13970CP443_RS13975CP443_RS13980CP443_RS13990CP443_RS13995CP443_RS14000CP443_RS14005
Location: 2864872..2866083 (1212 bp)
Type: Others
Protein ID: WP_003900845.1
Location: 2866210..2866869 (660 bp)
Type: Others
Protein ID: WP_003900846.1
Location: 2866866..2867528 (663 bp)
Type: Others
Protein ID: WP_003900848.1
Location: 2867525..2867803 (279 bp)
Type: Others
Protein ID: WP_003901422.1
Location: 2867896..2868309 (414 bp)
Type: Others
Protein ID: WP_003413164.1
Location: 2868348..2868605 (258 bp)
Type: Others
Protein ID: WP_003413167.1
Location: 2868602..2868979 (378 bp)
Type: Others
Protein ID: WP_003413174.1
Location: 2868995..2869369 (375 bp)
Type: Others
Protein ID: WP_003413177.1
Location: 2869469..2869864 (396 bp)
Type: Toxin
Protein ID: WP_003413180.1
Location: 2869861..2870106 (246 bp)
Type: Antitoxin
Protein ID: WP_003413183.1
Location: 2870517..2870936 (420 bp)
Type: Others
Protein ID: WP_003413190.1
Location: 2870948..2871757 (810 bp)
Type: Others
Protein ID: WP_003413193.1
Location: 2871754..2873007 (1254 bp)
Type: Others
Protein ID: WP_003413196.1
Location: 2873000..2873512 (513 bp)
Type: Others
Protein ID: WP_003413197.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CP443_RS139302864872..2866083+1212WP_003900845.1alpha/beta hydrolase family protein-
CP443_RS139402866210..2866869+660WP_003900846.1LppA family lipoprotein-
CP443_RS139452866866..2867528+663WP_003900848.1hypothetical protein-
CP443_RS139502867525..2867803+279WP_003901422.1type II toxin-antitoxin system VapB family antitoxin-
CP443_RS139552867896..2868309+414WP_003413164.1PIN domain nuclease-
CP443_RS139602868348..2868605+258WP_003413167.1ribbon-helix-helix domain-containing protein-
CP443_RS139652868602..2868979+378WP_003413174.1type II toxin-antitoxin system VapC family toxin-
CP443_RS139702868995..2869369-375WP_003413177.1hypothetical protein-
CP443_RS139752869469..2869864-396WP_003413180.1type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20Toxin
CP443_RS139802869861..2870106-246WP_003413183.1type II toxin-antitoxin system antitoxin VapB20Antitoxin
CP443_RS139902870517..2870936-420WP_003413190.1A24 family peptidase-
CP443_RS139952870948..2871757-810WP_003413193.1shikimate dehydrogenase-
CP443_RS140002871754..2873007-1254WP_003413196.1endolytic transglycosylase MltG-
CP443_RS140052873000..2873512-513WP_003413197.1Holliday junction resolvase RuvX-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endonuclease VapC20-like

(1-129)

Antitoxin

Ribbon-helix-helix protein, CopG

(11-49)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14619.53 Da        Isoelectric Point: 6.9794

>T82558 WP_003413180.1 NZ_CP023587:c2869864-2869469 [Mycobacterium tuberculosis]
MIFVDTSFWAALGNAGDARHGTAKRLWASKPPVVMTSNHVLGETWTLLNRRCGHRAAVAAAAIRLSTVVRVEHVTADLEE
QAWEWLVRHDEREYSFVDATSFAVMRKKGIQNAYAFDGDFSAAGFVEVRPE

Download         Length: 396 bp

>T82558 NZ_CP023587:c2869864-2869469 [Mycobacterium tuberculosis]
ATGATCTTCGTCGACACGTCCTTCTGGGCTGCACTTGGCAACGCCGGCGACGCTCGGCACGGCACCGCGAAGAGGTTGTG
GGCCAGCAAACCGCCCGTGGTGATGACCTCCAACCATGTCCTGGGCGAGACCTGGACGCTGCTCAACCGGCGCTGCGGTC
ACCGCGCGGCGGTTGCCGCCGCTGCAATCCGCTTGAGCACCGTCGTTCGCGTCGAGCACGTAACAGCCGACCTGGAAGAG
CAGGCATGGGAATGGCTTGTACGCCACGACGAGCGAGAGTACTCGTTCGTCGATGCCACGAGCTTCGCGGTGATGCGAAA
GAAAGGCATCCAAAATGCGTATGCCTTCGATGGTGACTTCAGCGCGGCCGGATTTGTCGAGGTAAGACCCGAGTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9098.33 Da        Isoelectric Point: 5.6007

>AT82558 WP_003413183.1 NZ_CP023587:c2870106-2869861 [Mycobacterium tuberculosis]
MLVAYICHVKRLQIYIDEDVDRALAVEARRRRTSKAALIREYVAEHLRQPGPDPVDAFVGSFVGEADLSASVDDVVYGKH
E

Download         Length: 246 bp

>AT82558 NZ_CP023587:c2870106-2869861 [Mycobacterium tuberculosis]
ATGCTAGTGGCGTATATTTGCCATGTGAAAAGGCTGCAGATCTACATCGACGAAGACGTTGACCGAGCGCTTGCTGTTGA
AGCGCGACGGCGGCGGACGTCGAAGGCGGCGCTGATCCGGGAGTACGTCGCTGAGCACCTCCGGCAGCCGGGCCCAGATC
CGGTCGATGCCTTCGTCGGATCGTTCGTGGGGGAAGCCGACTTGTCCGCGTCCGTCGACGACGTGGTTTACGGAAAGCAC
GAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB5WZ4
PDB5WZF

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7U4BW31

References