Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 752806..753439 Replicon chromosome
Accession NZ_CP023587
Organism Mycobacterium tuberculosis strain ME1473

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag CP443_RS03540 Protein ID WP_003403365.1
Coordinates 752806..753189 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag CP443_RS03545 Protein ID WP_003403368.1
Coordinates 753284..753439 (-) Length 52 a.a.

Genomic Context

CP443_RS03515CP443_RS03520CP443_RS03530CP443_RS03535CP443_RS03575CP443_RS03525CP443_RS03540CP443_RS03545CP443_RS03550CP443_RS03555CP443_RS03560CP443_RS03565CP443_RS03570
Location: 748126..748662 (537 bp)
Type: Others
Protein ID: WP_003403341.1
Location: 748699..749091 (393 bp)
Type: Others
Protein ID: WP_003403353.1
Location: 749822..751327 (1506 bp)
Type: Others
Protein ID: WP_003403360.1
Location: 751408..752418 (1011 bp)
Type: Others
Protein ID: WP_009937374.1
Location: 755959..758322 (2364 bp)
Type: Others
Protein ID: WP_003898547.1
Location: 749084..749779 (696 bp)
Type: Others
Protein ID: WP_003403355.1
Location: 752806..753189 (384 bp)
Type: Toxin
Protein ID: WP_003403365.1
Location: 753284..753439 (156 bp)
Type: Antitoxin
Protein ID: WP_003403368.1
Location: 753515..754231 (717 bp)
Type: Others
Protein ID: WP_003403371.1
Location: 754507..754815 (309 bp)
Type: Others
Protein ID: WP_003403376.1
Location: 754802..755047 (246 bp)
Type: Others
Protein ID: WP_003403381.1
Location: 755157..755594 (438 bp)
Type: Others
Protein ID: WP_003403386.1
Location: 755591..755845 (255 bp)
Type: Others
Protein ID: WP_003911263.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CP443_RS03515748126..748662+537WP_003403341.150S ribosomal protein L10-
CP443_RS03520748699..749091+393WP_003403353.150S ribosomal protein L7/L12-
CP443_RS03525749084..749779-696WP_003403355.1TetR/AcrR family transcriptional regulator-
CP443_RS03530749822..751327+1506WP_003403360.1carotenoid cleavage oxygenase-
CP443_RS03535751408..752418+1011WP_009937374.1ABC transporter ATP-binding protein-
CP443_RS03540752806..753189-384WP_003403365.1ribonuclease VapC6Toxin
CP443_RS03545753284..753439-156WP_003403368.1type II toxin-antitoxin system VapB family antitoxinAntitoxin
CP443_RS03550753515..754231-717WP_003403371.1CPBP family intramembrane metalloprotease-
CP443_RS03555754507..754815-309WP_003403376.1type II toxin-antitoxin system PemK/MazF family toxin-
CP443_RS03560754802..755047-246WP_003403381.1ribbon-helix-helix protein, CopG family-
CP443_RS03565755157..755594-438WP_003403386.1type II toxin-antitoxin system VapC family toxin-
CP443_RS03570755591..755845-255WP_003911263.1antitoxin VapB7-
CP443_RS03575755959..758322+2364WP_003898547.1arylsulfatase AtsD-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T82526 WP_003403365.1 NZ_CP023587:c753189-752806 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T82526 NZ_CP023587:c753189-752806 [Mycobacterium tuberculosis]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT82526 WP_003403368.1 NZ_CP023587:c753439-753284 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT82526 NZ_CP023587:c753439-753284 [Mycobacterium tuberculosis]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBG0TQD6

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7U4BSF8

References