Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
Location | 3109974..3110544 | Replicon | chromosome |
Accession | NZ_CP023583 | ||
Organism | Mycobacterium tuberculosis strain MDRDM260 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | P71650 |
Locus tag | CP439_RS15320 | Protein ID | WP_003414166.1 |
Coordinates | 3109974..3110330 (-) | Length | 119 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | P0CL61 |
Locus tag | CP439_RS15325 | Protein ID | WP_003901465.1 |
Coordinates | 3110314..3110544 (-) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CP439_RS15300 | 3105426..3107114 | - | 1689 | WP_003414155.1 | alpha/beta hydrolase family protein | - |
CP439_RS15305 | 3107118..3107444 | - | 327 | WP_003414157.1 | hypothetical protein | - |
CP439_RS15310 | 3107617..3108204 | + | 588 | WP_003914429.1 | DUF3558 family protein | - |
CP439_RS15315 | 3108223..3109872 | + | 1650 | WP_003899485.1 | CocE/NonD family hydrolase | - |
CP439_RS15320 | 3109974..3110330 | - | 357 | WP_003414166.1 | type II toxin-antitoxin system toxin endoribonuclease MazF9 | Toxin |
CP439_RS15325 | 3110314..3110544 | - | 231 | WP_003901465.1 | antitoxin MazE | Antitoxin |
CP439_RS15330 | 3110587..3111630 | - | 1044 | WP_003414172.1 | DUF2293 domain-containing protein | - |
CP439_RS15335 | 3111821..3112096 | + | 276 | WP_003911993.1 | DUF1778 domain-containing protein | - |
CP439_RS21540 | 3112272..3112526 | - | 255 | WP_003917684.1 | hypothetical protein | - |
CP439_RS15345 | 3112674..3113078 | + | 405 | WP_009938577.1 | hypothetical protein | - |
CP439_RS15350 | 3113075..3113266 | + | 192 | WP_003414184.1 | hypothetical protein | - |
CP439_RS15355 | 3113330..3114619 | + | 1290 | Protein_2900 | transposase family protein | - |
CP439_RS15360 | 3114853..3115110 | + | 258 | WP_003899489.1 | hypothetical protein | - |
CP439_RS15365 | 3115215..3115526 | + | 312 | WP_003414190.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 119 a.a. Molecular weight: 12858.73 Da Isoelectric Point: 9.1962
>T82321 WP_003414166.1 NZ_CP023583:c3110330-3109974 [Mycobacterium tuberculosis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS
Download Length: 357 bp
>T82321 NZ_CP023583:c3110330-3109974 [Mycobacterium tuberculosis]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG
Antitoxin
Download Length: 77 a.a. Molecular weight: 8231.01 Da Isoelectric Point: 4.1809
>AT82321 WP_003901465.1 NZ_CP023583:c3110544-3110314 [Mycobacterium tuberculosis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR
Download Length: 231 bp
>AT82321 NZ_CP023583:c3110544-3110314 [Mycobacterium tuberculosis]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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