Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2854119..2854759 Replicon chromosome
Accession NZ_CP023582
Organism Mycobacterium tuberculosis strain LN3756

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ08
Locus tag CP438_RS13840 Protein ID WP_003412970.1
Coordinates 2854119..2854538 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ09
Locus tag CP438_RS13845 Protein ID WP_003412975.1
Coordinates 2854535..2854759 (-) Length 75 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP438_RS13810 2849704..2850426 - 723 WP_003412957.1 DUF1906 domain-containing protein -
CP438_RS13820 2850943..2851170 + 228 WP_003412960.1 type II toxin-antitoxin system VapB family antitoxin -
CP438_RS13825 2851167..2851568 + 402 WP_003412963.1 PIN domain-containing protein -
CP438_RS13830 2851603..2852523 - 921 WP_003412965.1 restriction endonuclease -
CP438_RS21865 2852864..2853109 - 246 WP_071854223.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
CP438_RS13835 2853168..2854118 + 951 WP_003911916.1 Lsr2 family protein -
CP438_RS13840 2854119..2854538 - 420 WP_003412970.1 type II toxin-antitoxin system VapC family toxin Toxin
CP438_RS13845 2854535..2854759 - 225 WP_003412975.1 antitoxin VapB39 Antitoxin
CP438_RS13850 2854790..2857633 - 2844 WP_003899363.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
CP438_RS13855 2857705..2858106 - 402 WP_003412981.1 hypothetical protein -
CP438_RS13860 2858106..2858576 - 471 WP_003899364.1 transcription antitermination factor NusB -
CP438_RS13865 2858579..2859142 - 564 WP_003412989.1 elongation factor P -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-128)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 140 a.a.        Molecular weight: 14732.70 Da        Isoelectric Point: 6.7519

>T82252 WP_003412970.1 NZ_CP023582:c2854538-2854119 [Mycobacterium tuberculosis]
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL

Download         Length: 420 bp

>T82252 NZ_CP023582:c2854538-2854119 [Mycobacterium tuberculosis]
GTGACGGCACTGCTCGATGTCAATGTGCTGATCGCGCTGGGCTGGCCGAATCACGTTCACCATGCGGCCGCGCAGCGATG
GTTCACGCAGTTCTCCTCGAATGGGTGGGCCACCACGCCGATCACCGAGGCAGGGTATGTCCGAATTTCAAGCAATCGCA
GTGTGATGCAGGTGTCGACCACGCCGGCTATCGCGATCGCTCAGTTGGCGGCGATGACTTCTCTTGCCGGGCACACGTTT
TGGCCTGACGATGTGCCACTGATCGTTGGGAGCGCCGGCGATCGCGATGCGGTGTCCAACCACCGTCGGGTCACCGACTG
CCATCTCATCGCCTTGGCCGCGCGCTACGGGGGCCGGTTGGTCACATTCGATGCCGCACTGGCCGATTCAGCATCCGCAG
GCCTCGTCGAGGTGTTGTAG

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 7993.94 Da        Isoelectric Point: 4.0057

>AT82252 WP_003412975.1 NZ_CP023582:c2854759-2854535 [Mycobacterium tuberculosis]
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV

Download         Length: 225 bp

>AT82252 NZ_CP023582:c2854759-2854535 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGCAGATTGATGATGATGTTCTAGAAGATGCTCGTAGCATCGCGCGGTCGGAGGGCAAGTCAGTCGG
CGCGGTAATTTCTGAGTTGGCGCGTAGGTCGCTCCGTCCGGTTGGGATTGTCGAGGTTGACGGATTTCCGGTTTTTGATG
TTCCGCCGGATGCGCCGACGGTGACTTCCGAGGATGTCGTCCGCGCGCTCGAGGACGACGTGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TQ08


Antitoxin

Source ID Structure
AlphaFold DB G0TQ09

References