Detailed information of TA system TA082242

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 2203549..2204093
• Replicon: chromosome
• Accession: NZ_CP023582
• Organism: Mycobacterium tuberculosis strain LN3756

Toxin (Protein)

• Gene name: parE
• Uniprot ID: G0TLU9
• Locus tag: CP438_RS10630
• Protein ID: WP_003409896.1
• Coordinates: 2203549..2203845 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: CP438_RS10635
• Protein ID: WP_070892843.1
• Coordinates: 2203842..2204093 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CP438_RS10575	2198582..2198932	-	351	WP_003899096.1	hypothetical protein	-
CP438_RS10580	2198943..2199845	-	903	WP_003899097.1	hypothetical protein	-
CP438_RS10585	2199866..2200057	-	192	WP_003409876.1	hypothetical protein	-
CP438_RS10590	2200058..2200354	-	297	WP_003409877.1	hypothetical protein	-
CP438_RS10595	2200594..2200809	+	216	WP_003409878.1	antitoxin	-
CP438_RS10600	2200806..2201117	+	312	WP_003409881.1	type II toxin-antitoxin system VapC family toxin	-
CP438_RS21820	2201091..2201612	-	522	WP_003904745.1	hypothetical protein	-
CP438_RS10610	2201587..2201964	+	378	WP_010886136.1	type II toxin-antitoxin system toxin HigB	-
CP438_RS10615	2202006..2202455	+	450	WP_003409886.1	type II toxin-antitoxin system antitoxin HigA	-
CP438_RS10620	2202452..2202997	+	546	WP_003409891.1	SecB-like chaperone	-
CP438_RS10625	2202886..2203500	-	615	WP_003901296.1	hypothetical protein	-
CP438_RS10630	2203549..2203845	-	297	WP_003409896.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CP438_RS10635	2203842..2204093	-	252	WP_070892843.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
CP438_RS10640	2204080..2204574	+	495	WP_003899099.1	hypothetical protein	-
CP438_RS10645	2204734..2205141	-	408	WP_003409913.1	type II toxin-antitoxin system VapC family toxin	-
CP438_RS10650	2205145..2205417	-	273	WP_003899100.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
CP438_RS10655	2205450..2206670	-	1221	WP_003409919.1	TetR family transcriptional regulator Mce3R	-
CP438_RS10670	2207569..2208366	+	798	WP_003899101.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-93)

Antitoxin

• Antitoxin ParD (2-80)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11268.64 Da
• Isoelectric Point: 6.8604

>T82242 WP_003409896.1 NZ_CP023582:c2203845-2203549 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Nucleotide

• Length: 297 bp

>T82242 NZ_CP023582:c2203845-2203549 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9221.20 Da
• Isoelectric Point: 7.0150

>AT82242 WP_070892843.1 NZ_CP023582:c2204093-2203842 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSATEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Nucleotide

• Length: 252 bp

>AT82242 NZ_CP023582:c2204093-2203842 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCACTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCAGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Structures

Toxin

• AlphaFold DB: G0TLU9