Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 1388573..1389132 Replicon chromosome
Accession NZ_CP023582
Organism Mycobacterium tuberculosis strain LN3756

Toxin (Protein)


Gene name relE Uniprot ID G0THS1
Locus tag CP438_RS06805 Protein ID WP_003898789.1
Coordinates 1388573..1388866 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0THS2
Locus tag CP438_RS06810 Protein ID WP_003406322.1
Coordinates 1388863..1389132 (-) Length 90 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP438_RS06775 1384166..1384426 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 -
CP438_RS06780 1384423..1384854 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin -
CP438_RS06785 1384877..1386565 - 1689 WP_003910308.1 PE family protein -
CP438_RS06795 1386745..1387605 + 861 WP_003900301.1 hypothetical protein -
CP438_RS06800 1387686..1388516 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
CP438_RS06805 1388573..1388866 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
CP438_RS06810 1388863..1389132 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CP438_RS06815 1389245..1392940 - 3696 WP_003898790.1 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit -
CP438_RS06820 1393082..1393870 - 789 WP_003406325.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 98 a.a.        Molecular weight: 11031.57 Da        Isoelectric Point: 9.6275

>T82233 WP_003898789.1 NZ_CP023582:c1388866-1388573 [Mycobacterium tuberculosis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Download         Length: 294 bp

>T82233 NZ_CP023582:c1388866-1388573 [Mycobacterium tuberculosis]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9766.97 Da        Isoelectric Point: 4.8615

>AT82233 WP_003406322.1 NZ_CP023582:c1389132-1388863 [Mycobacterium tuberculosis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Download         Length: 270 bp

>AT82233 NZ_CP023582:c1389132-1388863 [Mycobacterium tuberculosis]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0THS1


Antitoxin

Source ID Structure
AlphaFold DB G0THS2

References