Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Rv0298-Rv0299/-
Location 363208..363734 Replicon chromosome
Accession NZ_CP023582
Organism Mycobacterium tuberculosis strain LN3756

Toxin (Protein)


Gene name Rv0299 Uniprot ID -
Locus tag CP438_RS01605 Protein ID WP_003401560.1
Coordinates 363432..363734 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name Rv0298 Uniprot ID -
Locus tag CP438_RS01600 Protein ID WP_031658821.1
Coordinates 363208..363435 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP438_RS01585 358937..359740 - 804 WP_003401540.1 hypothetical protein -
CP438_RS01590 359750..361147 - 1398 WP_003401544.1 sulfatase -
CP438_RS01595 361326..363065 + 1740 WP_031658820.1 PE family protein -
CP438_RS01600 363208..363435 + 228 WP_031658821.1 ribbon-helix-helix protein, CopG family Antitoxin
CP438_RS01605 363432..363734 + 303 WP_003401560.1 toxin-antitoxin system toxin Toxin
CP438_RS01610 363782..364003 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 -
CP438_RS01615 364000..364425 + 426 WP_003401566.1 PIN domain nuclease -
CP438_RS01620 364561..365193 + 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
CP438_RS01625 365190..366098 + 909 WP_003900117.1 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Ribbon-helix-helix protein, CopG

(6-41)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 10442.16 Da        Isoelectric Point: 4.9609

>T82210 WP_003401560.1 NZ_CP023582:363432-363734 [Mycobacterium tuberculosis]
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Download         Length: 303 bp

>T82210 NZ_CP023582:363432-363734 [Mycobacterium tuberculosis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8162.27 Da        Isoelectric Point: 7.0084

>AT82210 WP_031658821.1 NZ_CP023582:363208-363435 [Mycobacterium tuberculosis]
MTKEKISVTMDAAVLAAIDADARAAGLNRSEMIEQALRNEHLRVALRDYTAKTVPALDIDAYAQRVYQANRAAGS

Download         Length: 228 bp

>AT82210 NZ_CP023582:363208-363435 [Mycobacterium tuberculosis]
ATGACGAAAGAGAAGATCTCCGTGACGATGGACGCGGCCGTCCTCGCGGCGATCGACGCGGACGCCAGGGCGGCGGGTTT
GAATCGGTCGGAAATGATTGAGCAGGCACTGCGCAACGAGCACCTGCGTGTCGCTCTGCGCGATTACACGGCTAAAACCG
TACCGGCGTTGGACATCGATGCCTACGCACAGCGGGTGTACCAGGCGAACCGGGCGGCCGGAAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References