Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1764648..1765261 Replicon chromosome
Accession NZ_CP023581
Organism Mycobacterium tuberculosis strain LN2358

Toxin (Protein)


Gene name vapC Uniprot ID P64880
Locus tag CP437_RS08555 Protein ID WP_003407786.1
Coordinates 1764857..1765261 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8UJ46
Locus tag CP437_RS08550 Protein ID WP_009935474.1
Coordinates 1764648..1764851 (+) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP437_RS08520 1760053..1760433 + 381 WP_003407768.1 fumarate reductase subunit C -
CP437_RS08525 1760430..1760807 + 378 WP_003407771.1 fumarate reductase subunit FrdD -
CP437_RS08530 1760875..1761483 + 609 WP_003407773.1 TetR/AcrR family transcriptional regulator -
CP437_RS08535 1761667..1762815 + 1149 Protein_1613 MMPL family transporter -
CP437_RS08540 1762825..1763271 + 447 WP_003407780.1 F420H(2)-dependent quinone reductase -
CP437_RS08545 1763306..1764595 + 1290 WP_003407781.1 threonine ammonia-lyase -
CP437_RS08550 1764648..1764851 + 204 WP_009935474.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
CP437_RS08555 1764857..1765261 + 405 WP_003407786.1 type II toxin-antitoxin system toxin ribonuclease VapC11 Toxin
CP437_RS08560 1765278..1767020 - 1743 WP_003407788.1 malto-oligosyltrehalose trehalohydrolase -
CP437_RS08565 1767013..1769310 - 2298 WP_003407790.1 malto-oligosyltrehalose synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14650.76 Da        Isoelectric Point: 5.6587

>T82176 WP_003407786.1 NZ_CP023581:1764857-1765261 [Mycobacterium tuberculosis]
MILIDTSAWVEYFRATGSIAAVEVRRLLSEEAARIAMCEPIAMEILSGALDDNTHTTLERLVNGLPSLNVDDAIDFRAAA
GIYRAARRAGETVRSINDCLIAALAIRHGARIVHRDADFDVIARITNLQAASFR

Download         Length: 405 bp

>T82176 NZ_CP023581:1764857-1765261 [Mycobacterium tuberculosis]
ATGATCCTCATCGACACATCGGCCTGGGTGGAGTACTTCCGTGCCACCGGATCAATCGCCGCTGTCGAAGTACGCCGGCT
GCTGTCCGAAGAAGCAGCGCGAATCGCTATGTGTGAGCCCATTGCGATGGAAATCTTGAGTGGCGCGCTCGACGACAACA
CCCACACGACGCTAGAGCGGCTCGTGAATGGCTTGCCGTCGTTGAACGTTGATGACGCGATTGACTTTCGTGCTGCCGCG
GGTATCTATCGCGCCGCCCGGCGCGCCGGCGAAACGGTTCGAAGCATCAACGACTGCCTCATAGCGGCGCTCGCGATCCG
CCACGGTGCGCGTATCGTCCACCGTGACGCCGACTTTGATGTGATTGCCCGGATTACCAACCTGCAGGCCGCATCGTTTC
GGTGA

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7501.48 Da        Isoelectric Point: 4.3951

>AT82176 WP_009935474.1 NZ_CP023581:1764648-1764851 [Mycobacterium tuberculosis]
MSRTNIDIDDELAAEVMRRFGLTTKRAAVDLALRRLVGSPLSREFLLGLEGVGWEGDLDDLRSDRPD

Download         Length: 204 bp

>AT82176 NZ_CP023581:1764648-1764851 [Mycobacterium tuberculosis]
ATGTCGCGCACCAACATCGACATCGATGACGAACTTGCCGCCGAGGTCATGCGCAGGTTCGGTCTGACCACCAAGAGGGC
GGCGGTCGACCTTGCCCTACGACGGTTGGTCGGGTCGCCGTTGAGCCGTGAGTTTCTGCTCGGGCTGGAAGGCGTCGGCT
GGGAAGGCGACCTGGATGACTTGCGAAGCGATCGCCCAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6A7V

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8UJ46

References